VSIG1 - V-set and immunoglobulin domain containing 1 Gene

Also Known as GPA34; dJ889N15.1; 1700062D20Rik

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 340547

About VSIG1

Cytogenetic location: Xq22.3 Genomic coordinates (GRCh38): X:108,018,879-108,079,184 (from NCBI)

This gene has 5 transcripts (splice variants), 164 orthologues and 14 paralogues. Biased expression in stomach (RPKM 88.2), testis (RPKM 34.6) and 1 other tissue.

Summary

This gene encodes a member of the junctional adhesion molecule (JAM) family. The encoded protein contains multiple glycosylation sites at the N-terminal region, and multiple phosphorylation sites and glutamic acid/proline (EP) repeats at the C-terminal region. The gene is expressed in normal stomach and testis, as well as in gastric, esophageal and ovarian cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

VSIG1 Products (2)

mRNA Protein Name
NM_001170553.2 NP_001164024.1 V-set and immunoglobulin domain-containing protein 1 isoform 1 precursor
NM_182607.5 NP_872413.1 V-set and immunoglobulin domain-containing protein 1 isoform 2 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VSIG1 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (23 - 129)

Ig_2

Ig_2: Immunoglobulin domain (151 - 227)

  • 0
  • 100
  • 200
  • 300
  • 387 a.a.
Protein Preferred Names Protein Names

V-set and immunoglobulin domain-containing protein 1

  • cell surface A33 antigen

VSIG1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
VSIG1 Q86XK7 NINJ2 Homo sapiens Q9NZG7
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant VSIG1 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P71675 VSIG1 Protein, Human (HEK293, His) Q86XK7-1 (V22-E232) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Mucinous Lung Adenocarcinoma
Ovarian Cystadenoma

  • Cystoma Serosum Simplex

  • Simple Cystoma Of Ovary

  • Simple Cystoma Of The Ovary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS15706 VSIG1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19494 Vsig1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25988 Vsig1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus VSIG1 MGD MGI:1926039
Canis familiaris VSIG1 VGNC VGNC:54610
Bos taurus VSIG1 VGNC VGNC:56959
Rattus norvegicus VSIG1 RGD RGD:1565570
Felis catus VSIG1 VGNC VGNC:66976
Macaca mulatta VSIG1 VGNC VGNC:79734
Others VSIG1 NCBI