country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-163143

Copy Link Print Information

HDAC8-IN-6

HDAC8-IN-6 (compound 3) is a potent HDAC8 inhibitor with an IC₅₀ of 5.1 μM. HDAC8-IN-6 shows cytotoxicity.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 3036403-81-0
Formel: C₁₉H₁₈IN₃O₂
Molecular Weight:447.27

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

HDAC8-IN-6 Chemical Structure

CAS. Nr.: 3036403-81-0

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

HDAC8-IN-6 (compound 3) is a potent HDAC8 inhibitor with an IC₅₀ of 5.1 μM. HDAC8-IN-6 shows cytotoxicity^[1].

IC₅₀ & Target^[1]

HDAC8

5.1 μM (IC₅₀)

HDAC4

23.1 μM (IC₅₀)

Alle HDAC Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HEL	IC₅₀	>200 μM Compound: 3	Cytotoxicity against HEL cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay Cytotoxicity against HEL cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay	[PMID: 38113354]
HL-60	IC₅₀	161 μM Compound: 3	Cytotoxicity against human HL-60 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay Cytotoxicity against human HL-60 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay	[PMID: 38113354]
MOLM-13	IC₅₀	7.08 μM Compound: 3	Cytotoxicity against human MOLM-13 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay Cytotoxicity against human MOLM-13 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay	[PMID: 38113354]
MV4-11	IC₅₀	8.23 μM Compound: 3	Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay	[PMID: 38113354]
OCI-AML-3	IC₅₀	27.17 μM Compound: 3	Cytotoxicity against human OCI-AML-3 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay Cytotoxicity against human OCI-AML-3 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay	[PMID: 38113354]
SET-2	IC₅₀	>200 μM Compound: 3	Cytotoxicity against human SET2 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay Cytotoxicity against human SET2 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay	[PMID: 38113354]
THP-1	IC₅₀	46.5 μM Compound: 3	Cytotoxicity against human THP-1 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay Cytotoxicity against human THP-1 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay	[PMID: 38113354]

Chemical Information

CAS. Nr. 3036403-81-0
Molecular Weight 447.27
Formel C₁₉H₁₈IN₃O₂
SMILES

C[N+]1=CC=C(NC(CC(N2CC3=C(C=CC=C3)C2)=O)=O)C(C#C)=C1.[I-]
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Keeley AB, et al. Electrophilic MiniFrags Revealed Unprecedented Binding Sites for Covalent HDAC8 Inhibitors. J Med Chem. 2024 Jan 11;67(1):572-585. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

Angebot einholen Auf Lager

Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
Chemical Information
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

HDAC8-IN-6

Alle HDAC Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

HDAC8-IN-6 Related Classifications

HY-163143 Related Classifications