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Art. -Nr.: HY-189092

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HPPD-IN-14

HPPD-IN-14 is an inhibitor of Arabidopsis thaliana 4-hydroxyphenylpyruvate dioxygenase (AtHPPD), with an IC₅₀ of 0.188 μM and a K_i of 0.0077 μM. HPPD-IN-14 forms a stable complex through coordination with the active-site metal ion and multiple non-covalent interactions, thereby inhibiting the growth of target weeds, and exhibits high safety to wheat. HPPD-IN-14 can be used in herbicide-related research.

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CAS. Nr.: 2776994-70-6
Formel: C₂₁H₂₁F₃N₂O₅
Molecular Weight:438.40

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

HPPD-IN-14 Chemical Structure

CAS. Nr.: 2776994-70-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

AtHPPD

0.188 μM (IC₅₀)

AtHPPD

0.0077 μM (Ki)

In Vitro

HPPD-IN-14 (II-36) inhibits purified Arabidopsis thaliana HPPD with an IC₅₀ of 0.188 μM^[1].
HPPD-IN-14 (II-36) binds to Arabidopsis thaliana HPPD with a binding free energy of -8.778 kcal/mol, via metal chelation, π-π stacking, and hydrophobic interactions with key active site residues^[1].
HPPD-IN-14 (II-36) (0.05-0.09 μM; 30 min) acts as a slow-binding inhibitor of purified Arabidopsis thaliana HPPD, with an inhibition constant (K_i) of 0.0077 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2776994-70-6
Molecular Weight 438.40
Formel C₂₁H₂₁F₃N₂O₅
SMILES

O=C1CCCC(O)=C1C(C2=CC=C(N=C(C(F)(F)F)N(CCOCC)C3=O)C3=C2C)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Zhang WJ, et al. Discovery of Triketone-Quinazolinone Hybrids as Novel 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors. Journal of agricultural and food chemistry. 2026 Aug 12;74(31):24185-24197.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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