Lavengratinib
Lavengratinib (ABSK061) is a FGFR2/FGFR3 inhibitor. Lavengratinib selectively inhibits FGFR2 and FGFR3 signaling pathways and reduces the risk of FGFR1-mediated hyperphosphatemia. Lavengratinib is suitable for research on advanced solid tumors (including cholangiocarcinoma, gastric cancer, non-small cell lung cancer, cervical cancer and urothelial cancer).
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 2412854-49-8
- Formel: C26H27Cl2N5O4
- Molecular Weight:544.43
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
FGFR2 |
FGFR3 |
In Vitro
Resistance to Lavengratinib (ABSK061) involves secondary mutations in the kinase domains of FGFR2/3 and off-target alterations in the RTK/RAS and DDR pathways[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2412854-49-8
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Molecular Weight 544.43
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Formel C26H27Cl2N5O4
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SMILES
O=C1C(C2=C(C(OC)=CC(OC)=C2Cl)Cl)=CC3=CN=C(C4=CN(CCN5CCOCC5)N=C4)C=C3N1C
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Synonyms
ABSK061
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Lavengratinib Related Classifications
HY-187793 Related Classifications
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