country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-P99721

Copy Link Print Information

Biologically Validated

Lutikizumab

(Synonyms: ABT-981)

Kundenbewertung

Based on 1 Customer Validation

Lutikizumab (ABT-981) is an anti-IL-1α and IL-1β dual variable domain immunoglobulin. Lutikizumab binds and inhibits IL-1α and IL-1β. Lutikizumab can be used for the research of osteoarthritis.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 96.54%
CAS. Nr.: 1791411-57-8
Molecular Weight:196.57 kDa

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Lutikizumab Chemical Structure

CAS. Nr.: 1791411-57-8

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Anwendung
- Verified Bioactivity
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Isotype

[VH-VH'-H-Gamma1_VL-VL'-C-kappa]-dimer

Recommend Isotype Controls

Human IgG1 kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

IL-1a & IL1b

Alle Interleukin Related Isoform-spezifische Produkte anzeigen :

In Vitro

ABT-981 shows simultaneously binding efficacy human IL-α and IL-1β molecules^[1].
ABT-981 shows highly specific binding effects to IL-α and IL-1β over other IL-1 family members^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Lutikizumab (0.0001-1 mg/kg, i.p., once) shows effective inhibition to the IL-6 production induced by IL-1α and IL-1β^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Female C57/BL6 mice with IL-1α and IL-1β injection^[1]
Dosage:

0.0001-1 mg/kg
Administration:

Intraperitoneal injection, 0.0001-1 mg/kg, once
Result:

Dose-dependently decreased the murine IL-6 generated by human and cynomolgus IL-1α and IL-1β.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Gene ID

3552 [NCBI] & 3553 [NCBI]

Accession

P01583 & P01584

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

[VH-VH'-H-Gamma1_VL-VL'-C-kappa]-dimer

Anwendung

ELISA, FACS, Functional assay

Verified Bioactivity

Immobilized Human IL-1 alpha/IL1A Protein can bind Lutikizumab. The EC₅₀ for this effect is 1.97 ng/mL.
Immobilized Human IL-1 beta Protein can bind Lutikizumab. The EC₅₀ for this effect is 3.63 ng/mL.

Chemical Information

CAS. Nr. 1791411-57-8
Appearance Liquid
Molecular Weight 196.57 kDa
Color Colorless to light yellow
SMILES

[Lutikizumab]
Synonyms

ABT-981
Versand

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (258 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

Verweise

[1]. Lacy SE, et al. Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-Ig(TM)) molecule that specifically and potently neutralizes both IL-1α and IL-1β. MAbs. 2015;7(3):605-19. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen

Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Anwendung
- Biological Activity
Chemical Information
Reinheit & Dokumentation
Verweise

1/16

[VH-VH'-H-Gamma1_VL-VL'-C-kappa]-dimer
1/16

Immobilized Human IL-1 alpha/IL1A Protein can bind Lutikizumab. The EC₅₀ for this effect is 1.97 ng/mL.
1/16

Immobilized Human IL-1 beta Protein can bind Lutikizumab. The EC₅₀ for this effect is 3.63 ng/mL.
1/16

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

Lutikizumab

Canakinumab

Spesolimab

Secukinumab

Astegolimab

Nidanilimab (Nadunolimab)

Sonelokimab

Gevokizumab

Adalimumab

Bimekizumab

Raleukin

Tocilizumab

CAN10

Alle Interleukin Related Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Lutikizumab

Cell-ATP Viability Detection Kit

HOLO Human Interleukin-2 (IL-2) Detection Kit

Protein A Agarose

Bradford Protein Assay Kit

PBS Buffer (1×)

DPBS Buffer (1×)

Cytotoxicity LDH Assay Kit

Canakinumab

Spesolimab

Secukinumab

Astegolimab

Nidanilimab (Nadunolimab)

Sonelokimab

Gevokizumab

Adalimumab

Bimekizumab

Raleukin

Tocilizumab

CAN10

Alle Interleukin Related Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Lutikizumab Related Classifications

HY-P99721 Related Classifications