Art. -Nr.: HY-147914

NSD2-IN-1

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NSD2-IN-1 (compound 38) is a potent and high selective NSD2-PWWP1 (nuclear receptor-binding SET domain 2-PWWP1) inhibitor, with an IC₅₀ of 0.11 μM. NSD2-IN-1 can bind to NSD2-PWWP1 and then affect the expression of genes regulated by NSD2. NSD2-IN-1 induces apoptosis and cell cycle arrest.

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Reinheit: 98.72%
CAS. Nr.: 2797183-37-8
Formel: C₂₉H₃₁N₅
Molecular Weight:449.59

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

NSD2-IN-1 Chemical Structure

CAS. Nr.: 2797183-37-8

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

IC₅₀: 0.11 ± 0.01 μM (NSD2)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
KMS-11	IC₅₀	8.43 μM Compound: 38	Antiproliferative activity against human KMS-11 cells assessed as inhibition of cell proliferation measured after 6 days by CCK8 assay Antiproliferative activity against human KMS-11 cells assessed as inhibition of cell proliferation measured after 6 days by CCK8 assay	[PMID: 35704853]
KMS-11	IC₅₀	8.43 μM Compound: 15	Antiproliferative activity against human KMS-11 cells assessed as inhibition of cell growth Antiproliferative activity against human KMS-11 cells assessed as inhibition of cell growth	[PMID: 37578463]
MM1.S	IC₅₀	10.95 μM Compound: 38	Antiproliferative activity against human MM1.S cells assessed as inhibition of cell proliferation measured after 6 days by CCK8 assay Antiproliferative activity against human MM1.S cells assessed as inhibition of cell proliferation measured after 6 days by CCK8 assay	[PMID: 35704853]
MM1.S	IC₅₀	10.95 μM Compound: 15	Antiproliferative activity against human MM1.S cells assessed as inhibition of cell growth Antiproliferative activity against human MM1.S cells assessed as inhibition of cell growth	[PMID: 37578463]
MV4-11	IC₅₀	2.23 μM Compound: 38	Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell proliferation measured after 6 days by CCK8 assay Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell proliferation measured after 6 days by CCK8 assay	[PMID: 35704853]
MV4-11	IC₅₀	2.23 μM Compound: 15	Antiproliferative activity against human MV4-11 cells Antiproliferative activity against human MV4-11 cells	[PMID: 37578463]
RS4-11	IC₅₀	6.3 μM Compound: 38	Antiproliferative activity against human RS4-11 cells assessed as inhibition of cell proliferation measured after 6 days by CCK8 assay Antiproliferative activity against human RS4-11 cells assessed as inhibition of cell proliferation measured after 6 days by CCK8 assay	[PMID: 35704853]

In Vitro

NSD2-IN-1 inhibits cell proliferation in MV4:11, RS4:11, KMS11, and MM1S cells, with IC₅₀ values of 2.23, 6.30, 8.43, and 10.95 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2797183-37-8
Appearance Solid
Molecular Weight 449.59
Formel C₂₉H₃₁N₅
Color Off-white to light yellow
SMILES

CN1C=NC(C2=C(C=C(C=C2C)CN3CCC(CC3)N)C)=C1C4=CC=C(C5=C4C=CC=C5)C#N
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 50 mg/mL (111.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.2242 mL

11.1212 mL

22.2425 mL

5 mM

0.4448 mL

2.2242 mL

4.4485 mL

10 mM

0.2224 mL

1.1121 mL

2.2242 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (5.56 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (5.56 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (5.56 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Li N, et al. Structure-Based Discovery of a Series of NSD2-PWWP1 Inhibitors. J Med Chem. 2022 Jun 15. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.2242 mL	11.1212 mL	22.2425 mL	55.6062 mL
	5 mM	0.4448 mL	2.2242 mL	4.4485 mL	11.1212 mL
	10 mM	0.2224 mL	1.1121 mL	2.2242 mL	5.5606 mL
	15 mM	0.1483 mL	0.7414 mL	1.4828 mL	3.7071 mL
	20 mM	0.1112 mL	0.5561 mL	1.1121 mL	2.7803 mL
	25 mM	0.0890 mL	0.4448 mL	0.8897 mL	2.2242 mL
	30 mM	0.0741 mL	0.3707 mL	0.7414 mL	1.8535 mL
	40 mM	0.0556 mL	0.2780 mL	0.5561 mL	1.3902 mL
	50 mM	0.0445 mL	0.2224 mL	0.4448 mL	1.1121 mL
	60 mM	0.0371 mL	0.1854 mL	0.3707 mL	0.9268 mL
	80 mM	0.0278 mL	0.1390 mL	0.2780 mL	0.6951 mL
	100 mM	0.0222 mL	0.1112 mL	0.2224 mL	0.5561 mL

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NSD2-IN-1

Apoptosis Compound Library

Anti-Cancer Compound Library

Nuclear Receptor Compound Library

Heterocyclic Compound Library

Highly Selective Activators Library

Cell Death Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

NSD2-IN-1

Apoptosis Compound Library

Anti-Cancer Compound Library

Nuclear Receptor Compound Library

Heterocyclic Compound Library

Highly Selective Activators Library

Cell Death Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

NSD2-IN-1 Related Classifications

HY-147914 Related Classifications