Muc2 - mucin 2 Gene

Also Known as MCM; wnn; 2010015E03Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17831

Summary

Predicted to enable identical protein binding activity. Acts upstream of or within several processes, including epithelial cell development; negative regulation of cell migration; and positive regulation of apoptotic process. Located in extracellular matrix; inner mucus layer; and outer mucus layer. Is expressed in ileum and intestine. Used to study inflammatory bowel disease. Human ortholog(s) of this gene implicated in asthma. Orthologous to human MUC2 (Mucin 2, oligomeric mucus/gel-forming). [provided by Alliance of Genome Resources, Apr 2022]

Muc2 Products (1)

mRNA Protein Name
NM_023566.4 NP_076055.4 mucin-2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables extracellular matrix structural constituent IDA
IDA: Inferred from direct assay
35337837 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
19411636 MGI
Biological Process GO Annotation Evidence Références Source
acts upstream of or within apoptotic process IMP
IMP: Inferred from mutant phenotype
11872843 MGI
acts upstream of or within glandular epithelial cell development IMP
IMP: Inferred from mutant phenotype
11872843 MGI
involved in host-mediated regulation of intestinal microbiota composition IDA
IDA: Inferred from direct assay
33093110 MGI
involved in maintenance of gastrointestinal epithelium IDA
IDA: Inferred from direct assay
33093110 MGI
involved in mucus secretion IDA
IDA: Inferred from direct assay
35337837 MGI
acts upstream of or within negative regulation of cell migration IMP
IMP: Inferred from mutant phenotype
11872843 MGI
acts upstream of or within negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
11872843 MGI
acts upstream of or within positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
11872843 MGI
Cellular Component GO Annotation Evidence Références Source
located in extracellular matrix IDA
IDA: Inferred from direct assay
11352827 MGI
located in inner mucus layer IDA
IDA: Inferred from direct assay
18806221 MGI
is active in mucus layer IDA
IDA: Inferred from direct assay
35337837 MGI
located in outer mucus layer IDA
IDA: Inferred from direct assay
18806221 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mucin-2

  • colonic mucin

  • secreted gel-forming mucin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-E70562 Mucinase StcE Activator / Unkown
HY-158471 Core 1 O-glycan (C1) / Unkown
HY-RS08838 MUC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18623 Muc2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25109 Muc2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Muc2 NCBI NCBI:4583