MUC2 - mucin 2, oligomeric mucus/gel-forming Gene

Also Known as MLP; SMUC; MUC-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4583

About MUC2

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:1,074,875-1,110,508 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele, 116 orthologues and 19 paralogues. Biased expression in colon (RPKM 65.6), small intestine (RPKM 19.0) and 2 other tissues.

Summary

This gene encodes a member of the Mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Downregulation of this gene has been observed in patients with Crohn disease and ulcerative colitis. [provided by RefSeq, Oct 2016]

MUC2 Products (1)

mRNA Protein Name
NM_002457.4 NP_002448.4 mucin-2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables cupric ion binding IDA
IDA: Inferred from direct assay
36206754 GOA
enables cuprous ion binding IDA
IDA: Inferred from direct assay
36206754 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19359471 GOA
Biological Process GO Annotation Evidence References Source
involved in detoxification of copper ion IDA
IDA: Inferred from direct assay
36206754 GOA
involved in maintenance of gastrointestinal epithelium IMP
IMP: Inferred from mutant phenotype
17058067 GOA
involved in mucus secretion IMP
IMP: Inferred from mutant phenotype
17058067 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MUC2 Protein Structure

VWD

VWD: von Willebrand factor type D domain (37 - 178)

C8

C8: C8 domain (220 - 292)

TIL

TIL: Trypsin Inhibitor like cysteine rich domain (295 - 351)

VWD

VWD: von Willebrand factor type D domain (391 - 544)

C8

C8: C8 domain (582 - 654)

VWD

VWD: von Willebrand factor type D domain (860 - 1008)

C8

C8: C8 domain (1045 - 1118)

Mucin2_WxxW

Mucin2_WxxW: Mucin-2 protein WxxW repeating region (1305 - 1389)

VWD

VWD: von Willebrand factor type D domain (2119 - 2276)

C8

C8: C8 domain (2327 - 2392)

  • 0
  • 500
  • 1000
  • 1500
  • 2000
  • 2500
  • 2817 a.a.
Protein Preferred Names Protein Names

mucin-2

  • mucin 2, intestinal/tracheal

MUC2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MUC2 Q02817 AGR2 Homo sapiens O95994
Anti Bait CoIP
19359471
Intra
MUC2 Q02817 AGR2 Homo sapiens O95994
Anti Tag CoIP
19359471
Cross: Cross-species interaction Intra: Intraspecies interaction

MUC2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P80987 MUC2 Antibody (YA3529) WB, IHC-P, ICC/IF, IP, FC Human, Rat
HY-P84474 MUC2 Antibody (YA4171) IHC-P, FC, ELISA Human, Mouse, Rat, Rabbit
HY-P84474A MUC2 Antibody (YA4171)(PBS only) IHC-P, FC, ELISA Human, Mouse, Rat, Rabbit
HY-P85982 MUC2 Antibody (YA5674) IHC-P, ICC/IF, ELISA Human
HY-P86207 MUC2 Antibody (YA5899) WB, IHC-P, ICC/IF, IP, ELISA Human, Mouse, Rat

Related Diseases

Diseases Alias
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Pseudomyxoma Peritonei

  • Adenomucinosis

  • Gelatinous Ascites

  • Pmp

  • Mucinous Ascites

  • Syndrome Of Pseudomyxoma Peritonei
Pancreatic Ductal Carcinoma

  • Carcinoma, Pancreatic Ductal

  • Malignant Neoplasm Of Duct Of Wirsung

  • Pancreatic Duct Cancer

  • Carcinoma Pancreatic Ductal
Cystadenocarcinoma
Barrett Esophagus

  • Barrett'S Esophagus

  • Barrett Esophagus/Esophageal Adenocarcinoma

  • Barrett Metaplasia

  • Barrett'S Ulcer Of Esophagus

  • Ulcerative Esophagitis

  • Barrett'S Esophagus With Esophagitis

  • Barrett'S Oesophagus

  • Barretts Syndrome

  • Barrett Syndrome

  • BE

  • Peptic Ulcer Of Esophagus

  • Adenocarcinoma Of Esophagus
Ulcerative Colitis

  • Colitis Gravis

  • Left Sided Ulcerative Colitis

  • Left-Sided Ulcerative Colitis

  • Idiopathic Proctocolitis

  • Inflammatory Bowel Disease, Ulcerative Colitis Type

  • Uc

  • Colitis Ulcerative

  • Colitis, Ulcerative

  • Chronic Left-Sided Ulcerative Colitis

  • Uc - [Ulcerative Colitis]

  • Chronic Ulcerative Enteritis

  • Mucosal Proctocolitis

  • Ulcerative Mucosal Proctocolitis

  • Left Hemicolitis
Signet Ring Cell Adenocarcinoma

  • Signet Ring Cell Carcinoma

  • Carcinoma, Signet Ring Cell

  • Signet Ring Carcinoma

  • Carcinoma Signet Ring Cell
Colitis
Mucoepidermoid Carcinoma

  • Mec

  • Salivary Gland Mucoepidermoid Carcinoma

  • C3772

  • Carcinoma Mucoepidermoid

  • Carcinoma, Mucoepidermoid
Cholangiocarcinoma

  • Cholangiocarcinoma, Susceptibility To

  • Extrahepatic Cholangiocarcinoma

  • Intrahepatic Cholangiocarcinoma

  • Chlc

  • Chlc, Susceptibility To

  • Cc

  • Cholangiocarcinoma Of Biliary Tract

  • Cholangiocellular Carcinoma

  • Distal Cholangiocarcinoma

  • Perihilar Cholangiocarcinoma

  • Bile Duct Cancer

  • Cca

  • Adult Primary Cholangiocellular Carcinoma

  • Bile Duct Carcinoma
Tubular Adenocarcinoma

  • Tubular Carcinoma

  • Adenocarcinoma Tubular

  • Adenocarcinoma, Tubular
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Bladder Cancer

  • Urinary Bladder Cancer

  • Bladder Carcinoma

  • Urinary Bladder Carcinoma

  • Bladder Neoplasm

  • Bladder Tumor

  • Cancer, Bladder

  • Malignant Neoplasm Of Urinary Bladder

  • Carcinoma Of Bladder

  • Bladder Cancer, Somatic

  • Tumor Of The Bladder

  • Carcinoma Of Urinary Bladder

  • Bladder Carcinoma Urinary

  • Cancer Of The Urinary Bladder

  • Cancer, Urinary Bladder

  • Malignant Bladder Neoplasm

  • Malignant Bladder Tumor

  • Neoplasm Of The Bladder

  • Neoplasm Of The Urinary Bladder

  • Tumor Of The Urinary Bladder

  • Urinary Bladder Neoplasm

  • BLC

  • Urothelial Carcinoma Of The Bladder

  • Bladder Tumors

  • Urinary Bladder Neoplasms

  • Bladder Cancer Nos

  • Vesical Cancer Nos

  • Malignant Neoplasm Of Bladder, Part Unspecified

  • Malignant Tumour Of Urinary Bladder

  • Primary Malignant Neoplasm Of Bladder
Pancreatic Cancer

  • Pancreatic Carcinoma

  • Carcinoma Of Pancreas

  • Familial Pancreatic Carcinoma

  • Pancreatic Neoplasm

  • Pancreatic Carcinoma, Familial

  • Malignant Neoplasm Of Pancreas

  • Pancreatic Acinar Carcinoma

  • Pancreatic Tumor

  • Familial Pancreatic Cancer

  • Neoplasm Of The Pancreas

  • Cancer Of The Pancreas

  • Pancreatic Carcinoma, Somatic

  • Pancreatic Cancer, Somatic

  • Ca Body Of Pancreas

  • Ca Head Of Pancreas

  • Ca Tail Of Pancreas

  • Malignant Neoplasm Of Body Of Pancreas

  • Malignant Neoplasm Of Head Of Pancreas

  • Malignant Neoplasm Of Tail Of Pancreas

  • Pancreas Neoplasm

  • Exocrine Cancer

  • Exocrine Pancreas Carcinoma

  • Hereditary Pancreatic Cancer

  • Hereditary Pancreatic Carcinoma

  • PNCA

  • Pancreatic Cancer, Susceptibility To

  • Carcinoma Of Head Of Pancreas

  • Pancreatic Neoplasms

  • Pancreatic Tumors

  • Cancer, Pancreatic

  • Cancer Of Pancreas

  • Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Gallbladder Cancer

  • Gallbladder Carcinoma

  • Gallbladder Neoplasm

  • Malignant Neoplasm Of Gallbladder

  • Malignant Tumour Of Gallbladder

  • Gallbladder Ca

  • Localized Malignant Gallbladder Neoplasm

  • Malignant Tumor Of The Gallbladder

  • Tumor Of The Gallbladder

  • Cancer Of The Gallbladder

  • Carcinoma Gallbladder

  • Carcinoma Of Gallbladder

  • Gallbladder Neoplasms

  • Malignant Neoplasm Of Gallbladder Localized

  • Cancer Of Gallbladder

  • Primary Malignant Neoplasm Of Gallbladder
Atrophic Gastritis

  • Gastritis, Atrophic

  • Gastric Atrophy

  • Gastritis Atrophic
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-E70562 Mucinase StcE Activator / Unkown
HY-158471 Core 1 O-glycan (C1) / Unkown
HY-RS08838 MUC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18623 Muc2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25109 Muc2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MUC2 MGD MGI:1339364
Rattus norvegicus MUC2 RGD RGD:3123