CXCL10 - C-X-C motif chemokine ligand 10 Gene
Also Known as C7; IFI10; INP10; IP-10; crg-2; mob-1; SCYB10; gIP-10
Species: Homo sapiens
About CXCL10
This gene has 1 transcript (splice variant), 99 orthologues and 12 paralogues. Broad expression in appendix (RPKM 54.9), lymph node (RPKM 28.7) and 14 other tissues.
Summary
This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. This gene may also be a key regulator of the 'cytokine storm' immune response to SARS-CoV-2 Infection. [provided by RefSeq, Sep 2020]
CXCL10 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_001565.4 | NP_001556.2 | C-X-C motif chemokine 10 precursor |
| Molecular Function GO Annotation | Evidence | Références | Source |
|---|---|---|---|
| enables CXCR3 chemokine receptor binding |
IDA
IDA: Inferred from direct assay
|
12782716 | GOA |
| enables chemoattractant activity |
IDA
IDA: Inferred from direct assay
|
11157474 | GOA |
| enables chemokine activity |
IDA
IDA: Inferred from direct assay
|
12782716 | GOA |
| enables heparin binding |
IMP
IMP: Inferred from mutant phenotype
|
18645041 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
18275857 | GOA |
| Cellular Component GO Annotation | Evidence | Références | Source |
|---|---|---|---|
| located in extracellular region |
IDA
IDA: Inferred from direct assay
|
20041150 | GOA |
CXCL10 Protein Structure
IL8: Small cytokines (intecrine/chemokine), interleukin-8 like (28 - 88)
- 0
- 98 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
C-X-C motif chemokine 10 |
|
CXCL10 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | Références |
|---|---|---|---|---|---|---|---|
|
Intra
|
CXCL10 | P02778 | PF4 | Homo sapiens | P02776 | 28381538 | |
|
Intra
|
CXCL10 | P02778 | CCL5 | Homo sapiens | P13501 | 28381538 | |
|
Intra
|
CXCL10 | P02778 | CCL5 | Homo sapiens | P13501 | 28381538 | |
|
Intra
|
CXCL10 | P02778 | CXCL9 | Homo sapiens | Q07325 | 28381538 | |
|
Intra
|
CXCL10 | P02778 | CXCL12 | Homo sapiens | P48061 | 28381538 | |
|
Intra
|
CXCL10 | P02778 | CXCL12 | Homo sapiens | P48061 | 28381538 | |
|
Intra
|
CXCL10 | P02778 | CCL13 | Homo sapiens | Q99616 | 28381538 | |
|
Intra
|
CXCL10 | P02778 | CCL11 | Homo sapiens | P51671 | 28381538 | |
|
Intra
|
CXCL10 | P02778 | CCL28 | Homo sapiens | Q9NRJ3 | 28381538 | |
|
Intra
|
CXCL10 | P02778 | CCL26 | Homo sapiens | Q9Y258 | 28381538 | |
|
Intra
|
CXCL10 | P02778 | CCL21 | Homo sapiens | O00585 | 28381538 |
Recombinant CXCL10 Proteins
| Cat. No. | Nom du produit | Accession | Pureté |
|---|---|---|---|
| HY-P7226 | IP-10/CXCL10 Protein, Human | P02778 (V22-P98) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P700041AF | Animal-Free IP-10/CXCL10 Protein, Human (His) | P02778 (V22-P98) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P700532 | IP-10/CXCL10 Protein, Human (HEK293, His-Myc) | P02778 (V22-P98) | ≥ 90%, as determined by reducing SDS-PAGE. |
CXCL10 Anticorps
| Cat. No. | Nom du produit | Application | Reactivity |
|---|---|---|---|
| HY-P81154 | CXCL10/IP10 Antibody | ELISA, IHC-P, IHC-F, FC, ICC/IF | Human, Mouse, Rat, |
| HY-P82797 | IP10 Antibody (YA2542) | WB | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Spotted Fever |
|
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| Cryptosporidiosis |
|
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| Periapical Periodontitis |
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| Covid-19 |
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| Paracoccidioidomycosis |
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| Viral Meningitis |
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| Severe Acute Respiratory Syndrome |
|
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| Middle East Respiratory Syndrome |
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| Encephalitis |
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| Proliferative Glomerulonephritis |
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| Acrodermatitis |
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| Proteasome-Associated Autoinflammatory Syndrome 1 |
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| Cryoglobulinemia |
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| Hepatitis C |
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| Yellow Fever |
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| Contact Dermatitis |
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| Trypanosomiasis |
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| Neurosyphilis |
|
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| Viral Infectious Disease |
|
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| Uveitis |
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| Diverticulitis |
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| Rabies |
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| Alopecia Areata |
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| Vaccinia |
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| Malaria |
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| Pneumonia |
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| Thyroiditis |
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| Neuritis |
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| Critical Covid-19 |
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| Multiple Sclerosis |
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| Subacute Sclerosing Panencephalitis |
|
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| Neuromyelitis Optica |
|
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| Optic Neuritis |
|
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| Retinal Vein Occlusion |
|
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| Pyelonephritis |
|
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| Pulmonary Sarcoidosis |
|
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| Pustular Psoriasis |
|
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| Mycosis Fungoides |
|
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| Bronchiolitis |
|
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| Disseminated Intravascular Coagulation |
|
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| Bronchitis |
|
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| Graves' Disease |
|
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| Viral Pneumonia |
|
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| Pulmonary Tuberculosis |
|
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| Lung Disease |
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| Mumps |
|
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| Prostatitis |
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| Hepatitis A |
|
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| Coronavirus Infectious Disease |
|
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| Mycobacterium Tuberculosis 1 |
|
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| Severe Covid-19 |
|
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| Psoriatic Arthritis |
|
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| Aspergillosis |
|
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| Chagas Disease |
|
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| Psoriasis |
|
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| Inclusion Body Myositis |
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| Osteomyelitis |
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| Type 1 Diabetes Mellitus |
|
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| Myositis |
|
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| Liver Cirrhosis |
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| Avian Influenza |
|
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| Rheumatoid Arthritis |
|
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| Pulmonary Disease, Chronic Obstructive |
|
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| Retinal Detachment |
|
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| Allergic Contact Dermatitis |
|
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| Systemic Lupus Erythematosus |
|
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| Colitis |
|
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| Corneal Neovascularization |
|
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| Newcastle Disease |
|
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| Primary Cutaneous T-Cell Non-Hodgkin Lymphoma |
|
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| Non-Alcoholic Fatty Liver Disease |
|
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| Viral Encephalitis |
|
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| Inflammatory Bowel Disease |
|
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| Long Covid |
|
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| Asthma |
|
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| Sarcoidosis 1 |
|
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| Asymptomatic Neurosyphilis |
|
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| Respiratory Failure |
|
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| Allergic Disease |
|
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| Hantavirus Hemorrhagic Fever With Renal Syndrome |
|
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| Primary Bacterial Infectious Disease |
|
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| Microvascular Complications Of Diabetes 1 |
|
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| Interstitial Lung Disease 2 |
|
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| Temporal Arteritis |
|
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| Human Immunodeficiency Virus Type 1 |
|
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| Dermatitis, Atopic |
|
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| Ebola Hemorrhagic Fever |
|
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| Skin Disease |
|
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| West Nile Fever |
|
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| Childhood Type Dermatomyositis |
|
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| Extrapulmonary Tuberculosis |
|
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| Immune Deficiency Disease |
|
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| Thrombocytopenia |
|
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| Dengue Hemorrhagic Fever |
|
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| Genital Herpes |
|
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| Bacterial Pneumonia |
|
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| Bladder Cancer |
|
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| Irritant Dermatitis |
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| Autoimmune Disease |
|
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| Parasitic Protozoa Infectious Disease |
|
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| Tick-Borne Encephalitis |
|
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| Common Cold |
|
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| Meningoencephalitis |
|
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| Hemophagocytic Lymphohistiocytosis |
|
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| Conjunctival Disease |
|
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| Type 2 Diabetes Mellitus |
|
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| Chorioretinitis |
|
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| Autoimmune Disease Of Skin And Connective Tissue |
|
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| Lymph Node Disease |
|
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| Bronchopneumonia |
|
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| Bacterial Sepsis |
|
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| Autoimmune Disease Of Central Nervous System |
|
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| Bronchial Disease |
|
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| Extrinsic Cardiomyopathy |
|
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| Autoimmune Disease Of Musculoskeletal System |
|
|
| Leprosy 3 |
|
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| Melanoma |
|
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| Coccidiosis |
|
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| Leukocyte Disease |
|
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| Breast Cancer |
|
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| Diabetes Mellitus |
|
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| Integumentary System Disease |
|
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| Pancreatic Cancer |
|
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| Cystic Fibrosis |
|
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| Potocki-Shaffer Syndrome |
|
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| Visceral Leishmaniasis |
|
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| Aicardi-Goutieres Syndrome |
|
|
| Lipoprotein Quantitative Trait Locus |
|
|
| Hypertension, Essential |
|
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| Behcet Syndrome |
|
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| Connective Tissue Disease |
|
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| Celiac Disease 1 |
|
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| Eye Disease |
|
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| Nervous System Disease |
|
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| Peripheral Nervous System Disease |
|
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Macaca mulatta | CXCL10 | VGNC | VGNC:100213 |
| Felis catus | CXCL10 | VGNC | VGNC:107323 |
| Canis familiaris | CXCL10 | VGNC | VGNC:49645 |
| Rattus norvegicus | CXCL10 | RGD | RGD:620209 |
| Mus musculus | CXCL10 | MGD | MGI:1352450 |
| Bos taurus | CXCL10 | VGNC | VGNC:27846 |
| Others | CXCL10 | NCBI |