DIXDC1 - DIX domain containing 1 Gene

Also Known as CCD1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 85458

About DIXDC1

Cytogenetic location: 11q23.1 Genomic coordinates (GRCh38): 11:111,927,315-112,022,653 (from NCBI)

This gene has 9 transcripts (splice variants), 273 orthologues and 3 paralogues. Ubiquitous expression in brain (RPKM 11.3), endometrium (RPKM 10.0) and 23 other tissues.

Summary

The protein encoded by this gene is a positive regulator of the Wnt signaling pathway. The encoded protein is found associated with gamma tubulin at the centrosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]

DIXDC1 Products (3)

mRNA Protein Name
NM_001037954.4 NP_001033043.1 dixin isoform a
NM_001278542.2 NP_001265471.1 dixin isoform c
NM_033425.5 NP_219493.1 dixin isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables gamma-tubulin binding IDA
IDA: Inferred from direct assay
19375513 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17043677 GOA
Biological Process GO Annotation Evidence Références Source
involved in canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
21189423 GOA
Cellular Component GO Annotation Evidence Références Source
located in cytosol IDA
IDA: Inferred from direct assay
19375513 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DIXDC1 Protein Structure

CH

CH: Calponin homology (CH) domain (24 - 126)

DIX

DIX: DIX domain (598 - 678)

  • 0
  • 200
  • 400
  • 600
  • 682 a.a.
Protein Preferred Names Protein Names

dixin

  • coiled-coil protein DIX1

DIXDC1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Cross
DIXDC1 Q155Q3 Dvl2 Mus musculus Q60838
NMR
21189423
Intra
DIXDC1 Q155Q3 DVL2 Homo sapiens O14641
Anti Bait CoIP
20823832
Intra
DIXDC1 Q155Q3 NDEL1 Homo sapiens Q9GZM8
Y2H
17043677
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • Obesity , Susceptibility To

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS03785 DIXDC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris DIXDC1 VGNC VGNC:39969
Macaca mulatta DIXDC1 VGNC VGNC:71694
Bos taurus DIXDC1 VGNC VGNC:28077
Rattus norvegicus DIXDC1 RGD RGD:1309902
Mus musculus DIXDC1 MGD MGI:2679721
Felis catus DIXDC1 VGNC VGNC:102875
Others DIXDC1 NCBI