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Cat. No.: HY-W039803

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HDAC4 ligand-2

Name: HDAC4 ligand-2
Brand: MedChemExpress
SKU: HY-W039803
Price: 25.00 USD
Availability: InStock
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HDAC4 ligand-2 is a HDAC4 ligand, which can be used for the synthesis of PROTACs, such as PROTAC HDAC4 Degrader-2 (HY-184524).

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CAS No.: 340736-76-7
Formule: C₁₀H₅F₃N₂O₃
Masse moléculaire:258.15

Stockage:

Store at room temperature 3 years.

In solvent -80°C, 2 years , -20°C, 1 year

HDAC4 ligand-2 Chemical Structure

CAS No.: 340736-76-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureté et documentation
Références
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Help & FAQs
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Activité biologique

Description

HDAC4 ligand-2 is a HDAC4 ligand, which can be used for the synthesis of PROTACs, such as PROTAC HDAC4 Degrader-2 (HY-184524)^[1].

IC₅₀ & Target^[1]

HDAC4

Voir tous les produits spécifiques à Isoform HDAC :

Cellular Effect

Cell Line	Type	Value	Description	References
MT2	CC₅₀	82.25 μM Compound: B10	Cytotoxicity against human MT2 cells after 4 days by XTT assay Cytotoxicity against human MT2 cells after 4 days by XTT assay	[PMID: 19053778]
MT2	EC₅₀	3.06 μM Compound: B10	Antiviral activity against HIV1 3B in human MT2 cells assessed as inhibition of p24 antigen level after 4 days by ELISA Antiviral activity against HIV1 3B in human MT2 cells assessed as inhibition of p24 antigen level after 4 days by ELISA	[PMID: 19053778]

Chemical Information

CAS No. 340736-76-7
Appearance Solid
Masse moléculaire 258.15
Formule C₁₀H₅F₃N₂O₃
SMILES

O=C(C1=CC=C(C=C1)C2=NOC(C(F)(F)F)=N2)O
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Macabuag N, et al. Developing HDAC4-Selective Protein Degraders To Investigate the Role of HDAC4 in Huntington's Disease Pathology. J Med Chem. 2022 Sep 22;65(18):12445-12459. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
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- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références

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HDAC4 ligand-2

Voir tous les produits spécifiques à Isoform HDAC