PRMT4-IN-1
PRMT4-IN-1 is a selective inhibitor of PRMT4 (IC50=3.2 nM). PRMT4-IN-1 inhibits MCF7 relative viability.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 3035425-70-5
- Formule: C30H36N10O7
- Masse moléculaire:648.67
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Voir tous les produits spécifiques à Isoform Histone Methyltransferase
More
Activité biologique
|
PRMT1 0.835 μM (IC50) |
PRMT3 4.05 μM (IC50) |
PRMT4 3.2 nM (IC50) |
PRMT5 1.46 μM (IC50) |
PRMT6 1.75 μM (IC50) |
PRMT7 1.68 μM (IC50) |
PRMT8 1.95 μM (IC50) |
PRMT4-IN-1 (compound 12h) (10 μM, 50 μM, 100 μM; 24 h, 72 h) shows no effect on reduction the number of metabolically active cells[1]. PRMT4-IN-1 (50 μM; 2-8 d) decreases relative cell viability time-dependently in MCF7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 3035425-70-5
-
Masse moléculaire 648.67
-
Formule C30H36N10O7
-
SMILES
O[C@@H]1[C@H](O)[C@@H](/C=C/CNC(NCCCCNC(NC2=CC3=C(O)C=C(C(OC)=O)C=C3C=C2)=O)=N)O[C@H]1N4C=NC5=C(N)N=CN=C45
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Iannelli G, et al. Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach. J Med Chem. 2022 Sep 8;65(17):11574-11606. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz