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Art. -Nr.: HY-146228

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HSP90-IN-13

HSP90-IN-13 (compound 5k) is a highly potent HSP90 pan inhibitor with an IC₅₀ value of 25.07 nM. HSP90-IN-13 has multi-target activity against EGFR, VEGFR-2 and Topoisomerase-2. HSP90-IN-13 causes cell cycle arrest at G2/M phase and induces apoptosis of MCF-7 cells through mitochondrial-mediated pathway.

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CAS. Nr.: 2446055-29-2
Formel: C₂₆H₂₁N₅O₃S
Molecular Weight:483.54

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

HSP90-IN-13 Chemical Structure

CAS. Nr.: 2446055-29-2

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Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

HSP90

25.07 nM (IC₅₀)

Topoisomerase-2

25.85 nM (IC₅₀)

EGFR

38.5 nM (IC₅₀)

VEGFR-2

126.95 nM (IC₅₀)

Alle HSP Isoform-spezifische Produkte anzeigen :

Alle Topoisomerase Isoform-spezifische Produkte anzeigen :

Alle EGFR Isoform-spezifische Produkte anzeigen :

Alle VEGFR Isoform-spezifische Produkte anzeigen :

In Vitro

HSP90-IN-13 (compound 5k) arrests the cell cycle on MCF-7 at a G2/M phase by 35.06% and induced apoptosis by 19.82%^[1].
HSP90-IN-13 has anti-proliferative activity against HCT-116, Hela and MCF-7 cell lines with IC₅₀s of 4.47 μM, 7.55 μM and 4.04 μM, respectively^[1].
HSP90-IN-13 has potent multi-target inhibitory activities against EGFR, VEGFR-2 and Topoisomerase-2 with IC₅₀ values of 38.5 nM, 126.95 nM and 25.85 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2446055-29-2
Molecular Weight 483.54
Formel C₂₆H₂₁N₅O₃S
SMILES

O=C(C1=CC=CC(N2N=NC(CSC3=NC4=C(C(N3CC5=CC=CC=C5)=O)C=C(C)C=C4)=C2)=C1)O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. El-Shafey HW, et al. Synthetic approaches, anticancer potential, HSP90 inhibition, multitarget evaluation, molecular modeling and apoptosis mechanistic study of thioquinazolinone skeleton: Promising antibreast cancer agent. Bioorg Chem. 2020 Aug;101:10398 [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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HSP90-IN-13

Alle HSP Isoform-spezifische Produkte anzeigen

Alle Topoisomerase Isoform-spezifische Produkte anzeigen

Alle EGFR Isoform-spezifische Produkte anzeigen

Alle VEGFR Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

HSP90-IN-13 Related Classifications

HY-146228 Related Classifications