TRPC3/6-IN-1
Based on 1 Customer Validation
TRPC3/6-IN-1 is a potent selectivity blocker of the canonical transient receptor channels (TRPC3/6), has block potency for hTRPC3 and hTRPC6 with IC50 values of 1260 nM and 500 nM, respectively. TRPC3/6-IN-1 can be used for the research of chronic models of heart failure.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.20%
- CAS. Nr.: 736945-96-3
- Formel: C20H19N3O2S
- Molecular Weight:365.45
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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hTRPC3 1260 nM (IC50) |
hTRPC6 500 nM (IC50) |
TRPC3/6-IN-1 has block potency for hTRPC3 and hTRPC6 with IC50 values of 1260 nM and 500 nM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Pharmacokinetic Parameters of TRPC3/6-IN-1 in rats [1].
| Compd | Dose(iv)(mg/kg) | Cmax(iv)(ng/ml) | CL(iv)(ml/min/kg) | MRT(iv)(h) | DNAUC(iv)(h•kg/L) | %F |
| 3 | 0.93 | 250 | 120 | 0.3 | 0.14 | ~1 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 736945-96-3
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Appearance Solid
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Molecular Weight 365.45
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Formel C20H19N3O2S
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Color White to off-white
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SMILES
COC1=CC=C(NC2=NC(C(N3CCC4=C(C3)C=CC=C4)=O)=CS2)C=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Reinheit & Dokumentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
TRPC3/6-IN-1 Related Classifications
HY-147357 Related Classifications
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