HCV Protease
HCV NS3-4A serine protease is a critical enzyme in the hepatitis C virus life cycle, essential for polyprotein processing, RNA replication, and virion formation. It functions as a complex with NS4A and possesses both protease and NTPase/RNA helicase activities. This protease plays a key role in immune evasion by cleaving and inactivating host signaling molecules MAVS and TRIF, thereby suppressing interferon production. HCV infection leads to chronic liver diseases such as steatosis, fibrosis, cirrhosis, and hepatocellular carcinoma. Due to its pivotal role in viral replication and immune escape, the NS3-4A protease is a major target for antiviral drug development.
References:
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HCV Protease (2)
BI-1388
Cat. No.: HY-115516
CAS No.: 1309952-03-1
- Formula: C41H53N7O9S
- Molecular Weight: 819.97
YIC-C8-434
Cat. No.: HY-138198A
- Formula: C31H44N2O4
- Molecular Weight: 508.69
YIC-C8-434 is an orally active ACAT inhibitor. YIC-C8-434 selectively blocks cholesterol esterification in intestinal epithelial cells and hepatocytes without affecting the production of triglycerides or phospholipids. YIC-C8-434 effectively reduces intracellular cholesteryl ester levels and induces an increase in lipid droplet volume, exhibiting excellent cholesterol-lowering activity and safety. YIC-C8-434 disrupts the assembly of hepatitis C virus (HCV) virions, reduces HCV RNA synthesis and viral particle release. YIC-C8-434 can be used in studies related to hepatitis C virus infection.
