2. Disease Areas
  3. Infection
  4. Hepatitis Virus Infection
  5. HCV Protease

HCV Protease

HCV NS3-4A serine protease is a critical enzyme in the hepatitis C virus life cycle, essential for polyprotein processing, RNA replication, and virion formation. It functions as a complex with NS4A and possesses both protease and NTPase/RNA helicase activities. This protease plays a key role in immune evasion by cleaving and inactivating host signaling molecules MAVS and TRIF, thereby suppressing interferon production. HCV infection leads to chronic liver diseases such as steatosis, fibrosis, cirrhosis, and hepatocellular carcinoma. Due to its pivotal role in viral replication and immune escape, the NS3-4A protease is a major target for antiviral drug development.

HCV Protease (1):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-115516
    BI-1388 1309952-03-1
    BI-1388 is a macrocyclic acylsulfonamide-based HCV NS3-4A protease inhibitor. BI-1388 inhibits clinically relevant drug-resistant mutant strains (KRASD168V gt 1b and KRASR155K gt 1a) and exhibits high liver distribution. BI-1388 is applicable for the research of HCV infection.
    BI-1388