7-Deazaneplanocin A
7-Deazaneplanocin A is a carbocyclic nucleoside analog with anti-HCV activity and anti-HBV activity (EC50 0.60 µM). 7-Deazaneplanocin A exhibits activity against vaccinia virus and variola virus in vitro, with low cytotoxicity. 7-Deazaneplanocin A is applicable to studies related to viral infections.
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- CAS No.: 101843-93-0
- Formule: C12H14N4O3
- Masse moléculaire:262.26
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 2.2.15 | EC50 |
0.60 μM
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Antiviral activity against wild-type HBV in 2.2.15 cells assessed as reduction of extracellular virion DNA levels via quantitative blot hybridization 24 hours after nine consecutive daily doses.
Antiviral activity against wild-type HBV in 2.2.15 cells assessed as reduction of extracellular virion DNA levels via quantitative blot hybridization 24 hours after nine consecutive daily doses.
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19072694 |
| HepG2 2.2.15 | IC50 |
22 μM
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Cytotoxicity in 2.2.15 cells assessed via neutral red dye uptake 24 hours after nine consecutive daily doses.
Cytotoxicity in 2.2.15 cells assessed via neutral red dye uptake 24 hours after nine consecutive daily doses.
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19072694 |
7-Deazaneplanocin A (compound 2) potently inhibits HCV replication in Huh7 ET cells with an EC50 of 2.5 μM; it also inhibits HCV replication in Huh7 Clone B cells with an EC50 of 0.9 μM and an EC90 of 8.2 μM, and shows no cytotoxicity at concentrations as high as 50 μM[1].
7-Deazaneplanocin A (administered for 9 consecutive days, evaluated 24 hours after the final dose) inhibits the replication of wild-type HBV in 2.2.15 cells, with an EC50 of 0.60 μM, and exhibits moderate cytotoxicity with an IC50 of 22 μM[1].
7-Deazaneplanocin A (compound 2) potently inhibits the replication of vaccinia virus and variola virus in human foreskin fibroblasts (HFF) without significant cytotoxicity, and its activity against these orthopoxviruses is superior to that of Cidofovir (HY-17438)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 101843-93-0
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Masse moléculaire 262.26
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Formule C12H14N4O3
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SMILES
NC1=NC=NC2=C1C=CN2[C@H]3[C@H](O)[C@H](O)C(CO)=C3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Kim HJ, et al. Synthesis and anti-hepatitis B virus and anti-hepatitis C virus activities of 7-deazaneplanocin A analogues in vitro. Journal of medicinal chemistry. 2009 Jan 08;52(1):206-13. [Content Brief]
[2]. Arumugham B, et al. Synthesis and antiviral activity of 7-deazaneplanocin A against orthopoxviruses (vaccinia and cowpox virus). Bioorganic & medicinal chemistry letters. 2006 Jan 15;16(2):285-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
7-Deazaneplanocin A Related Classifications
HY-188061 Related Classifications
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