EGFR/c-Met-IN-2
EGFR/ C-Met-in-2 (Compound H-22) is a dual inhibitor of EGFR/c-Met. EGFR/c-Met-IN-2 inhibits cell proliferation by arresting G2/M phase. EGFR/c-Met-IN-2 has antitumor activity.
For research use only. We do not sell to patients.
- CAS No.: 2761180-01-0
- Formula: C27H23F2N5O4
- Molecular Weight:519.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
2.76 μM
Compound: 2
|
Antiproliferative activity against human A549 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
|
[PMID: 38733884] |
| HeLa | IC50 |
2.32 μM
Compound: 2
|
Antiproliferative activity against human HeLa cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
|
[PMID: 38733884] |
| MCF7 | IC50 |
3.53 μM
Compound: 2
|
Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
|
[PMID: 38733884] |
| NCI-H1975 | IC50 |
2.27 μM
Compound: 2
|
Antiproliferative activity against human NCI-H1975 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
Antiproliferative activity against human NCI-H1975 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
|
[PMID: 38733884] |
| NCI-H460 | IC50 |
2.48 μM
Compound: 2
|
Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
|
[PMID: 38733884] |
Chemical Information
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CAS No. 2761180-01-0
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Molecular Weight 519.50
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Formula C27H23F2N5O4
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SMILES
O=C(C=C)NC(C(OC)=C1)=CC2=C1N=CN=C2OC3=CC=C(NC(NCCC4=CC=C(F)C=C4)=O)C=C3F
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)