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  3. Drug Derivative
  4. EP4 receptor agonist 3 prodrug

EP4 receptor agonist 3 prodrug (Compound 9) is a prodrug of EP4 receptor agonist (Compound 1a). EP4 receptor agonist 3 prodrug itself has no agonistic activity on the EP4 receptor and needs to be specifically hydrolyzed by intestinal alkaline phosphatase (IAP) in the intestine to release the active molecule, which then exerts the EP4 receptor agonistic effect locally in the intestine. EP4 receptor agonist 3 prodrug has colonic targeting properties and significantly alleviates colitis in mice.

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EP4 receptor agonist 3 prodrug

EP4 receptor agonist 3 prodrug Chemical Structure

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EP4 receptor agonist 3 prodrug Related Antibodies

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Description

EP4 receptor agonist 3 prodrug (Compound 9) is a prodrug of EP4 receptor agonist (Compound 1a). EP4 receptor agonist 3 prodrug itself has no agonistic activity on the EP4 receptor and needs to be specifically hydrolyzed by intestinal alkaline phosphatase (IAP) in the intestine to release the active molecule, which then exerts the EP4 receptor agonistic effect locally in the intestine. EP4 receptor agonist 3 prodrug has colonic targeting properties and significantly alleviates colitis in mice[1].

Molecular Weight

503.47

Formula

C23H32F2NO7P
SMILES

FC([C@H](OCCP(O)(O)=O)/C=C/[C@@H]1N(CCCCCCC(O)=O)C(CC1)=O)(F)C2=CC=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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EP4 receptor agonist 3 prodrug Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EP4 receptor agonist 3 prodrugDrug DerivativeDrug derivativeEP4 receptor agonistProdrugGI-centricInflammatory bowel diseaseUlcerative colitisIntestinal alkaline phosphatase (IAP)DSS mouse modelMethylene phosphateTargeted deliveryInhibitorinhibitorinhibit

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EP4 receptor agonist 3 prodrug
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