FGFR4-IN-9

Cat. No.: HY-144759: Fiche technique Instruction de manipulation
FAQs
Technical Support

FGFR4-IN-9 (Compound 6O) is a selective FGFR4 inhibitor with an IC₅₀ of 75.3 nM. FGFR4-IN-9 effectively inhibits both the growth and angiogenesis of HCC.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

FGFR4-IN-9 Chemical Structure

CAS No. : 3033043-66-9

Size		Stock
MOQ		Minimum order quantity
50 mg		Obtenir un devis
100 mg		Obtenir un devis
250 mg		Obtenir un devis
Other size		Obtenir un devis

* Veuillez sélectionner la quantité avant d'ajouter des articles.

This product is a controlled substance and not for sale in your territory.

Recommandations en vedette

•Related Small Molecules:

•Related Proteins:

Activité biologique
Pureté et documentation
Références
Avis client

Description

FGFR4-IN-9 (Compound 6O) is a selective FGFR4 inhibitor with an IC₅₀ of 75.3 nM. FGFR4-IN-9 effectively inhibits both the growth and angiogenesis of HCC^[1].

IC₅₀ & Target

FGFR4

75.3 nM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
Hep 3B2	IC₅₀	0.9 μM Compound: 20	Antiproliferative activity against human Hep3B cells expressing FGFR2 assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human Hep3B cells expressing FGFR2 assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 37976704]
Hep 3B2	IC₅₀	4.5 μM Compound: 20	Antiproliferative activity against human Hep3B cells expressing FGFR3 assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human Hep3B cells expressing FGFR3 assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 37976704]
Huh-7	IC₅₀	12.6 μM Compound: 20	Antiproliferative activity against human Huh-7 cells expressing FGFR3 assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human Huh-7 cells expressing FGFR3 assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 37976704]
Huh-7	IC₅₀	7.1 μM Compound: 20	Antiproliferative activity against human Huh-7 cells expressing FGFR2 assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human Huh-7 cells expressing FGFR2 assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 37976704]

Masse moléculaire

522.90

Formule

C₂₄H₂₂ClF₃N₄O₄

CAS No.

3033043-66-9

SMILES

C=CC(NC1=CC(F)=CC(Cl)=C1NC2=NC(C)=C(C(C)=N2)OCC3=C(C(OC)=CC(OC)=C3F)F)=O

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Chaudhary CL, et al. 6-Amino-2,4,5-trimethylpyridin-3-ol and 2-amino-4,6-dimethylpyrimidin-5-ol derivatives as selective fibroblast growth factor receptor 4 inhibitors: design, synthesis, molecular docking, and anti-hepatocellular carcinoma efficacy evaluation. J Enzyme Inhib Med Chem. 2022 Dec;37(1):844-856. [Content Brief]

FGFR4-IN-9 Related Classifications

Calculateur de molarité
Calculateur de dilution

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FGFR4-IN-93033043-66-9FGFRFibroblast growth factor receptorHep3BHCCHuh7H6c7hepatocellular carcinomaantitumor effectInhibitorinhibitorinhibit

Vos produits récemment consultés:

Nom du produit

Requested Quantity *

Nom du demandeur *

Civilité

Adresse e-mail *

Numéro de téléphone *

Department

Nom de l'organisation *

City

État

Country or Region *

Remarques

Nom du produit

Lot #

Nom du demandeur *

Adresse e-mail *

Numéro de téléphone

Department *

Nom de l'organisation *

Country or Region *

Remarques

Nom
Email *

	Sorry, but the email address you supplied was invalid.

FGFR4-IN-9

FGFR4-IN-9 Related Antibodies

Recommandations en vedette

•Related Small Molecules:

•Related Proteins:

Activité biologique

Pureté et documentation

Références

Avis client

FGFR4-IN-9 Related Classifications

Calculateur de molarité

Calculateur de dilution