FMOC-3-azido-D-alanine
FMOC-3-azido-D-alanine is an Fmoc-protected azido amino acid derivative. FMOC-3-azido-D-alanine acts as a model substance in copper(I)-catalysed alkyne-azide cycloaddition reactions to test click chemistry conditions on solid support for ligation to alkyne-functionalized lysine dendrons.
For research use only. We do not sell to patients.
- CAS No.: 1016163-79-3
- Formula: C18H16N4O4
- Molecular Weight:352.34
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
FMOC-3-azido-D-alanine (Fmoc-D-Aza-OH) (2 eq.; 2 days) solid-phase copper(I)-catalysed cycloaddition to alkyne-functionalized lysine dendron achieves 92% yield when performed with 1.2 eq. CuI and 55 eq. DIPEA in DMF for 2 days at room temperature in the dark[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1016163-79-3
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Appearance Solid
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Molecular Weight 352.34
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Formula C18H16N4O4
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Color White to off-white
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SMILES
O=C(O)[C@@H](CN=[N+]=[N-])NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (283.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (644 KB)
- English - EN (644 KB)
- Français - FR (644 KB)
- Deutsch - DE (644 KB)
- Norwegian - NO (644 KB)
- Español - ES (644 KB)
- Swedish - SV (644 KB)
- Italian - IT (644 KB)
- Korean - KR (644 KB)
- Portuguese - PT (644 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8382 mL | 14.1908 mL | 28.3817 mL | 70.9542 mL |
| 5 mM | 0.5676 mL | 2.8382 mL | 5.6763 mL | 14.1908 mL | |
| 10 mM | 0.2838 mL | 1.4191 mL | 2.8382 mL | 7.0954 mL | |
| 15 mM | 0.1892 mL | 0.9461 mL | 1.8921 mL | 4.7303 mL | |
| 20 mM | 0.1419 mL | 0.7095 mL | 1.4191 mL | 3.5477 mL | |
| 25 mM | 0.1135 mL | 0.5676 mL | 1.1353 mL | 2.8382 mL | |
| 30 mM | 0.0946 mL | 0.4730 mL | 0.9461 mL | 2.3651 mL | |
| 40 mM | 0.0710 mL | 0.3548 mL | 0.7095 mL | 1.7739 mL | |
| 50 mM | 0.0568 mL | 0.2838 mL | 0.5676 mL | 1.4191 mL | |
| 60 mM | 0.0473 mL | 0.2365 mL | 0.4730 mL | 1.1826 mL | |
| 80 mM | 0.0355 mL | 0.1774 mL | 0.3548 mL | 0.8869 mL | |
| 100 mM | 0.0284 mL | 0.1419 mL | 0.2838 mL | 0.7095 mL |
FMOC-3-azido-D-alanine Related Classifications
HY-151638 Related Classifications
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Keywords
- FMOC-3-azido-D-alanine
- 1016163-79-3
- Drug Intermediate
- click chemistry
- copper(I)-catalysed alkyne-azide cycloaddition reactions
- DMF
- Fmoc-protected azido amino acid derivative
- room temperature
- CuI
- solid support
- solid-phase copper(I)-catalysed cycloaddition
- alkyne-functionalized lysine dendrons
- DIPEA
- Inhibitor
- inhibitor
- inhibit