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Cat. No.: HY-135225

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CH 402

CH 402 is an antioxidant and radioprotective agent. CH 402 reduces the level of ⁶⁰Co-γ ray-induced lipid peroxidation in in vitro liver microsomal preparations. CH 402 inhibits ascorbate-induced non-enzymatic lipid peroxidation in brain homogenates and microsomal fractions of rodents.

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CAS No.: 75903-70-7
Formule: C₁₂H₁₄NNaO₃S
Masse moléculaire:275.30

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Please store the product under the recommended conditions in the Certificate of Analysis.

CH 402 Chemical Structure

CAS No.: 75903-70-7

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
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Activité biologique

Description

In Vitro

CH 402 acts as a radioprotective agent by reducing lipid peroxidation induced by ⁶⁰Co-γ ray irradiation in liver microsomes of both amiodarone-treated and control rats^[1].
CH 402 (0-20 min) inhibits ascorbate-induced lipid peroxidation in brain homogenates and brain microsomal fractions of Wistar rats, as well as in brain homogenates and brain microsomal fractions of CBA/Ca mice, with an IC₅₀ of 0.5 mM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 75903-70-7
Masse moléculaire 275.30
Formule C₁₂H₁₄NNaO₃S
SMILES

O=S(CC1=CC(C)(C)NC2=C1C=CC=C2)(O[Na])=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Vereckei A, et al. The role of free radicals in the pathogenesis of amiodarone toxicity. Journal of cardiovascular electrophysiology. 1993 Apr;4(2):161-77.

[2]. Blázovics A, et al. Inhibition of lipid peroxidation by dihydroquinoline-type antioxidant (CH 402). Free radical research communications. 1988;4(6):409-13.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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