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Pirfenidone

(Synonyms: AMR69)
92 Cited Publications
Revisión del cliente

Based on 92 publication(s) in Google Scholar

Pirfenidone (AMR69) is an antifibrotic agent that attenuates CCL2 and CCL12 production in fibrocyte cells. Pirfenidone has growth-inhibitory effect and reduces TGF-β2 protein levels in human glioma cell lines. Pirfenidone also has anti-inflammatory activities.

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  • Pureza: 99.99%
  • No. CAS: 53179-13-8
  • Fòrmula: C12H11NO
  • Peso molecular:185.22
  • Almacenamiento:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • Pirfenidone Chemical Structure
    Pirfenidone Chemical Structure
  • Experimental Validation Results for Pirfenidone
  • Experimental Validation Results for Pirfenidone
  • Experimental Validation Results for Pirfenidone
  • Experimental Validation Results for Pirfenidone
  • Experimental Validation Results for Pirfenidone
  • Experimental Validation Results for Pirfenidone
No. CAS: 53179-13-8
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Encuentre su distribuidor local Your local distributor: Hycultec GmbHHycultec
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  • Pirfenidone Chemical Structure
    Pirfenidone Chemical Structure
    1/16
  • 1/16

    Pirfenidone purchased from MedChemExpress. Usage Cited in: Mater Today Bio. 2025 Apr 5:32:101729. [Abstract]

    Customer Validation
     NPCs treated with different doses of PFD (5-320 μM) for 24 h

  • 1/16

    Pirfenidone purchased from MedChemExpress. Usage Cited in: Mater Today Bio. 2025 Apr 5:32:101729. [Abstract]

    Customer Validation
     Pirfenidone (20 μM; 24 h) was used for calcein/PI detection in the above-mentioned treated NPCs (scale bar: 100 μm; n = 3).

  • 1/16

    Pirfenidone purchased from MedChemExpress. Usage Cited in: Mater Today Bio. 2023 Apr 25:20:100643. [Abstract]

    Customer Validation
     Pirfenidone (50 mg/kg; once every two days; 14 days) was administered. Representative transverse (top row) and coronal (bottom row) micro-CT scan images of the lungs in living mice were obtained.

  • 1/16

    Pirfenidone purchased from MedChemExpress. Usage Cited in: Sci Adv. 2022 Jun 17;8(24):eabn4564. [Abstract]

    Customer Validation
     Female mice (15 months old) were treated with pirfenidone via injection (250 mg/kg, ip; 4 days) or orally (500 mg/kg, po; 2 weeks) or with nintedanib (50 mg/kg, ip; 4 days) and compared to those treated with vehicle (Veh) and young (Y; 2 months old) controls.

  • 1/16

    Pirfenidone purchased from MedChemExpress. Usage Cited in: Sci Adv. 2022 Jun 17;8(24):eabn4564. [Abstract]

    Customer Validation
     Female mice (12 months old) were treated with pirfenidone orally (500 mg/kg; 2 weeks; n = 12) or vehicle (n = 16) alongside young controls (n = 8), and ovarian fibrosis was assessed by PSR staining.

  • 1/16

    Pirfenidone purchased from MedChemExpress. Usage Cited in: Radiat Res. 2018 Oct;190(4):396-403. [Abstract]

    Customer Validation
     Western blots are shown of collagen I, collagen III, TGF-b1, p-Smad3 and Smad3 proteins in lung tissue homogenates from different groups.

  • Pirfenidone