SR-4370
Based on 1 publication(s) in Google Scholar
SR-4370 is an inhibitor of HDAC, with IC50s of 0.13 μM, 0.58 μM, 0.006 μM, 2.3 μM, and 3.4 μM for HDAC1, HDAC2, HDAC3, HDAC8, and HDAC6, respectively.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.38%
- No. CAS: 1816294-67-3
- Fòrmula: C17H18F2N2O
- Peso molecular:304.33
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
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Publications Citing Use of MedChemExpress (MCE) SR-4370
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Actividad biológica
|
HDAC3 6 nM (IC50) |
HDAC1 130 nM (IC50) |
HDAC2 580 nM (IC50) |
HDAC8 2300 nM (IC50) |
HDAC6 3400 nM (IC50) |
SR-4370 is an inhibitor of HDAC, with IC50s of 0.13 μM, 0.58 μM, 0.006 μM, 2.3 μM, and 3.4 μM for HDAC1, HDAC2, HDAC3, HDAC8, and HDAC6, respectively. SR-4370 is cytotoxic to the breast cancer cells (MDA-MB-231), with an IC50 of 12.6 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 1816294-67-3
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Appearance Solid
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Peso molecular 304.33
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Fòrmula C17H18F2N2O
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Color White to off-white
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SMILES
O=C(C1=CC=C(C2=CC=CC(F)=C2F)C=C1)NNCCCC
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
Solvente y solubilidad
DMSO : ≥ 150 mg/mL (492.89 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (269 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2859 mL | 16.4295 mL | 32.8591 mL | 82.1477 mL |
| 5 mM | 0.6572 mL | 3.2859 mL | 6.5718 mL | 16.4295 mL | |
| 10 mM | 0.3286 mL | 1.6430 mL | 3.2859 mL | 8.2148 mL | |
| 15 mM | 0.2191 mL | 1.0953 mL | 2.1906 mL | 5.4765 mL | |
| 20 mM | 0.1643 mL | 0.8215 mL | 1.6430 mL | 4.1074 mL | |
| 25 mM | 0.1314 mL | 0.6572 mL | 1.3144 mL | 3.2859 mL | |
| 30 mM | 0.1095 mL | 0.5477 mL | 1.0953 mL | 2.7383 mL | |
| 40 mM | 0.0821 mL | 0.4107 mL | 0.8215 mL | 2.0537 mL | |
| 50 mM | 0.0657 mL | 0.3286 mL | 0.6572 mL | 1.6430 mL | |
| 60 mM | 0.0548 mL | 0.2738 mL | 0.5477 mL | 1.3691 mL | |
| 80 mM | 0.0411 mL | 0.2054 mL | 0.4107 mL | 1.0268 mL | |
| 100 mM | 0.0329 mL | 0.1643 mL | 0.3286 mL | 0.8215 mL |
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