BMP-4 (15-24) acetate
Based on 1 publication(s) in Google Scholar
BMP-4 (15-24) acetate is a cell-penetrating heparin-binding peptide with the sequence RKKNPNCRRH. BMP-4 (15-24) acetate exhibits anti-inflammatory and anti-chondrogenic activities. BMP-4 (15-24) acetate can be used in the research of arthritis.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.30%
- Fòrmula: C52H93N25O13S.xC2H4O2
- Peso molecular:1308.52 (free base)
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Almacenamiento:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) BMP-4 (15-24) acetate
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Actividad biológica
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IL-6 |
COX-2 |
BMP-4 (15-24) (0-100 μg/mL; 24 h) acetate inhibits the expression of inflammatory proteins including iNOS, COX2, IFNγ, and IL-6 in LPS (HY-D1056)-stimulated RAW264.7 macrophages[2].
BMP-4 (15-24) (0-100 μg/mL) acetate dose-dependently upregulates the mRNA expression of cartilage marker genes AGG, COLII, and TNFα in human articular chondrocytes NHAC[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LPS treated RAW264.7
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Concentration:0, 10, 50, 100 μg/mL
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Incubation Time:24 h
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Result:Inhibited the levels of iNOS, COX-2, IFNγ and IL6 in a dose-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:DBA/1 mice (male, 21-24 g, 7 weeks old) with collagen-induced arthritis (CIA)[2]
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Dosage:30 mg/kg
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Administration:subcutaneous injection; twice weekly for 4 consecutive weeks
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Result:Significantly reduced the arthritis score and hind paw swelling degree, and inhibits the serum concentrations of proinflammatory cytokines IFNγ and IL-6.
Alleviated synovial hyperplasia, pannus formation and bone erosion, and repairs the damage of glycosaminoglycan (GAG) area in articular cartilage.
Chemical Information
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Appearance Crystal
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Peso molecular 1308.52 (free base)
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Fòrmula C52H93N25O13S.xC2H4O2
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Color White to off-white
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Sequence
Arg-Lys-Lys-Asn-Pro-Asn-Cys-Arg-Arg-His
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Sequence Shortening
RKKNPNCRRH
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Mater Today Bio
Synergistic 3D-bioprinted scaffold with multi-level adaptability for vascularized bone regeneration via osteogenesis-angiogenesis coupling. [Abstract]2026 Jan 21:37:102837. PMID: 41660131
Solvente y solubilidad
H2O : 100 mg/mL (Need ultrasonic)
DMSO : 100 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Pureza y Documentación
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Ficha de datos (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Pathade V, et al. Emerging insights of peptide-based nanotherapeutics for effective management of rheumatoid arthritis. Life Sci. 2023 Jan 1;312:121257. [Content Brief]
[2]. Choi DH, et al. A Synthetic Cell-Penetrating Heparin-Binding Peptide Derived from BMP4 with Anti-Inflammatory and Chondrogenic Functions for the Treatment of Arthritis. Int J Mol Sci. 2020;21(12):4251. Published 2020 Jun 15. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BMP-4 (15-24) acetate Related Classifications
HY-P10710A Related Classifications
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