Cosdosiran
Based on 1 publication(s) in Google Scholar
Cosdosiran is a chemically modified siRNA designed to temporarily inhibit expression of the caspase 2 protein and can be used for the study of nonarteritic anterior ischemic optic neuropathy and other optic neuropathies such as glaucoma that result in the death of retinal ganglion cells.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.48%
- No. CAS: 1834560-88-1
- Peso molecular:12388.68
-
Almacenamiento:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications Citing Use of MedChemExpress (MCE) Cosdosiran
MoreVer todos los productos específicos de isoformas Caspase
More
Actividad biológica
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
-
No. CAS 1834560-88-1
-
Appearance Solid
-
Peso molecular 12388.68
-
Color White to off-white
-
SMILES
[Cosdosiran]
-
Synonyms
QPI-1007
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
J Vis Exp
Assessing Microglial Phagocytosis of Myelin Debris in vitro Under Repeated Magnetic Stimulation. [Abstract]2025 Jun 17:(220). PMID: 40622958
Pureza y Documentación
-
Ficha de datos (267 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Instrucciones de manejo (2242 KB)
Referencias
[1]. Solano EC, Kornbrust DJ, Beaudry A, Foy JW, Schneider DJ, Thompson JD. Toxicological and pharmacokinetic properties of QPI-1007, a chemically modified synthetic siRNA targeting caspase 2 mRNA, following intravitreal injection. Nucleic Acid Ther. 2014;24(4):258-266. doi:10.1089/nat.2014.0489 [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)