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Referencia número: HY-B1251

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Guanethidine

3 Cited Publications

Revisión del cliente

Based on 3 publication(s) in Google Scholar

Guanethidine sulphate was synthesized in 1959. Guanethidine is thought to lowing blood pressure by interfering with the metabolism of chemical transmitter substances in post-ganglionic sympathetic nerve fibres.

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No. CAS: 55-65-2
Fòrmula: C₁₀H₂₂N₄
Peso molecular:198.31

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Guanethidine Chemical Structure

No. CAS: 55-65-2

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Actividad biológica

Descripciòn

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In Vitro

Ablation of sympathetic fibers is associated with a loss of rat endothelial cell marker (RECA), but no significant effect of guanethidine was found on the survival of endothelial cells and mesenchymal stem cells in vitro^[1].
.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Guanethidine (30 mg/kg, s.c., 1 h) unaffected IL-18 hypernociception in TNFR1^(-/-) mice as a sympathetic blocker^[2].
.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wild-type (WT) Balb/c,TNFR1^(-/-)and IFN_-γ-γ^(-/-) mice^[2].
Dosage:

30 mg/kg
Administration:

Guanethidine (30 mg/kg, s.c., 1 h, diluted in saline)
Result:

Pre-treatment with guanethidine (sympathetic blocker) unaffected IL-18 hypernociception in TNFR1^(-/-) mice.

Chemical Information

No. CAS 55-65-2
Peso molecular 198.31
Fòrmula C₁₀H₂₂N₄
SMILES

NC(NCCN1CCCCCCC1)=N
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (3)

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Nat Commun

A gatekeeper sympathetic control of lacrimal tear secretion and dry eye onset through the NA-Adra1a-Ucp2 pathway. [Abstract]

2025 Jun 5;16(1):5215. PMID: 40473608
iScience

A stress-responsive neurovascular axis shapes skin immune accessibility. [Abstract]

2026 Feb 23;29(3):115122. PMID: 41852725
Authorea

September 19, 2022.

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Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. P Dubový, etal. Local chemical sympathectomy of rat bone marrow and its effect on marrow cell composition. [Content Brief]

[2]. Waldiceu A.VerriJr, etal. Antigen-induced inflammatory mechanical hypernociception in mice is mediated by IL-18. Brain Beha [Content Brief]

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1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Guanethidine

3 Cited Publications

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Guanethidine

Publications Citing Use of MedChemExpress (MCE) Guanethidine

Ver todos los productos específicos de isoformas Adrenergic Receptor

Actividad biológica

Chemical Information

Publications (3)

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Guanethidine Related Classifications

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