UCP1172
UCP1172 is an antibacterial (Antibacterial) agent and Dihydrofolate reductase inhibitor, with an IC50 of 0.0089 μM against Staphylococcus aureus DfrB, 0.22 μM against DfrG, 0.41 μM against DfrA, and 0.030 μM against DfrK. UCP1172 potently inhibits the growth of MRSA/MSSA isolates carrying dfrG and dfrK (MIC values of 0.3125-0.625 μg/mL), shows weak activity against MRSA carrying dfrA (MIC of 5 μg/mL), and exerts extremely potent inhibitory effects on wild-type S. aureus ATCC 43300 (MIC of 0.0098 μg/mL). UCP1172 can be used in studies related to tuberculosis and Staphylococcus aureus infections.
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- No. CAS: 1922152-04-2
- Fòrmula: C24H24N4O3
- Peso molecular:416.47
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF-10A | IC50 |
100 μM
Compound: 11R
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Cytotoxicity against human MCF10A cells after 4 hrs by alamar blue assay
Cytotoxicity against human MCF10A cells after 4 hrs by alamar blue assay
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[PMID: 27437079] |
UCP1172 (0.0098-5 μg/mL; 18 hr) potently inhibits the growth of dfrG- and dfrK-harboring MRSA/MSSA clinical isolates (MIC values 0.3125-0.625 μg/mL), shows weaker activity against dfrA-harboring MRSA (MIC 5 μg/mL), and highly potently inhibits wild-type S. aureus ATCC 43300 (MIC 0.0098 μg/mL)[2].
UCP1172 (0.0089-0.41 μM) potently inhibits wild-type S. aureus DfrB (IC50 0.0089 μM) and TMP-resistant DfrG (IC50 0.22 μM), DfrA (IC50 0.41 μM), and DfrK (IC50 0.030 μM) DHFR enzymes, with drastically improved potency over TMP for the resistant variants[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 1922152-04-2
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Peso molecular 416.47
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Fòrmula C24H24N4O3
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SMILES
CCC1=NC(N)=NC(N)=C1C#C[C@@H](C2=CC(OC)=CC(C3=CC=C(C=C3)C(O)=O)=C2)C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Ramharack P, et al. Dual-Target Mycobacterium tuberculosis Inhibition: Insights into the Molecular Mechanism of Antifolate Drugs. Int J Mol Sci. 2023 Sep 13;24(18):14021. [Content Brief]
[2]. Reeve SM, et al. MRSA Isolates from United States Hospitals Carry dfrG and dfrK Resistance Genes and Succumb to Propargyl-Linked Antifolates. Cell Chem Biol. 2016;23(12):1458-1467. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
UCP1172 Related Classifications
HY-185443 Related Classifications
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- UCP1172
- 1922152-04-2
- UCP 1172
- UCP-1172
- Bacterial
- Dihydrofolate reductase (DHFR)
- Mycobacterium tuberculosis RV2671
- Mycobacterium tuberculosis
- Staphylococcus aureus DfrA
- Staphylococcus aureus DfrK
- cytochrome P450 3A4
- methicillin-resistant Staphylococcus aureus
- Staphylococcus aureus DfrG
- methicillin-sensitive Staphylococcus aureus
- Mycobacterium tuberculosis DHFR
- Staphylococcus aureus DfrB
- Inhibitor
- inhibitor
- inhibit