ADAMTS13 - Adamts13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 102554393

Summary

Enables endopeptidase activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipopolysaccharide; and response to potassium ion. Located in extracellular space. Biomarker of cholestasis and non-alcoholic fatty liver disease. Human ortholog(s) of this gene implicated in thrombotic thrombocytopenic purpura. Orthologous to human ADAMTS13 (ADAM metallopeptidase with thrombospondin type 1 motif 13). [provided by Alliance of Genome Resources, Apr 2022]

ADAMTS13 Products (12)

mRNA	Protein	Name
XM_039106138.1	XP_038962066.1	A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform X7
XM_039106136.1	XP_038962064.1	A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform X5
XM_039106131.1	XP_038962059.1	A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform X2
XM_039106140.1	XP_038962068.1	A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform X9
XM_039106137.1	XP_038962065.1	A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform X6
XM_006233879.3	XP_006233941.3	A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform X1
XM_039106132.1	XP_038962060.1	A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform X3
XM_039106134.1	XP_038962062.1	A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform X4
XM_039106133.1	XP_038962061.1	A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform X4
XM_039106135.1	XP_038962063.1	A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform X4
XM_039106139.1	XP_038962067.1	A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform X8
XM_039106141.1	XP_038962069.1	A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform X10

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables endopeptidase activity	IDA IDA: Inferred from direct assay	19652891	RGD
enables peptidase activity	IDA IDA: Inferred from direct assay	16689760	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to interleukin-4	IEP IEP: Inferred from expression pattern	18433458	RGD
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	22871409	RGD
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	18433458	RGD
involved in cellular response to type II interferon	IEP IEP: Inferred from expression pattern	18433458	RGD
involved in protein catabolic process	IDA IDA: Inferred from direct assay	19652891	RGD
involved in response to amine	IEP IEP: Inferred from expression pattern	17383642	RGD
involved in response to interleukin-4	IEP IEP: Inferred from expression pattern	18433458	RGD
involved in response to potassium ion	IEP IEP: Inferred from expression pattern	17804457	RGD
involved in response to toxic substance	IEP IEP: Inferred from expression pattern	16689760	RGD
involved in response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	18433458	RGD
involved in response to type II interferon	IEP IEP: Inferred from expression pattern	18433458	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	19652891	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
A disintegrin and metalloproteinase with thrombospondin motifs 13	A disintegrin and metalloproteinase with thrombospondin motifs 13-like a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 mot

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P5354	FRETS-VWF73		97.30%	Unkown
HY-P5354A	FRETS-VWF73 TFA		97.44%	Unkown
HY-DP5354AF	Biotin-FRETS-VWF73 TFA		/	Unkown
HY-RS00294	ADAMTS13 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17864	Adamts13 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24333	Adamts13 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	ADAMTS13	NCBI	NCBI:11093