2. Gene
  3. Rps6ka3 - ribosomal protein S6 kinase polypeptide 3 Gene

Rps6ka3 - ribosomal protein S6 kinase polypeptide 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Rsk2; MPK-9; p90RSK3; pp90RSK2; MAPKAPK-1b; S6K-alpha3

Gene ID: 110651 | Gene type: protein coding

About Rps6ka3

Chromosome X: 157,993,303-158,151,240 forward strand.GRCm39:CM001013.3

This gene has 9 transcripts (splice variants), 252 orthologues, 7 paralogues and is associated with 44 phenotypes. Ubiquitous expression in subcutaneous fat pad adult (RPKM 6.8), genital fat pad adult (RPKM 5.9) and 26 other tissues.

Summary

Enables protein kinase binding activity and protein serine/threonine kinase activity. Involved in response to lipopolysaccharide and Toll-like Receptor signaling pathway. Predicted to be located in cytosol and nucleolus. Predicted to be active in cytoplasm and nucleoplasm. Is expressed in several structures, including alimentary system; blastocyst; branchial arch; central nervous system; and eye. Used to study Coffin-Lowry syndrome. Human ortholog(s) of this gene implicated in Coffin-Lowry syndrome; intellectual disability; and non-syndromic X-linked intellectual disability 19. Orthologous to human RPS6KA3 (ribosomal protein S6 kinase A3). [provided by Alliance of Genome Resources, Apr 2022]

Rps6ka3 Products(2)

mRNA Protein Name
NM_148945.2 NP_683747.1 ribosomal protein S6 kinase alpha-3 isoform 1
NM_001346675.1 NP_001333604.1 ribosomal protein S6 kinase alpha-3 isoform 2

Rps6ka3 Protein Structure

STKc_RSK_N

STKc_RSK_N: cd05582 (71 - 387)

STKc_RSK2_C

STKc_RSK2_C: cd14176 (401 - 739)

  • 0
  • 200
  • 400
  • 600
  • 740 a.a.
Protein Preferred Names Protein Names

ribosomal protein S6 kinase alpha-3

90 kDa ribosomal protein S6 kinase 3

MAP kinase-activated protein kinase 1b

MAPK-activated protein kinase 1b

MAPKAP kinase 1b

ribosomal protein S6 kinase 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-148061 DB1113 99.28% Unkown
HY-150643 RSK2-IN-2 Inhibitor / Unkown
HY-150717 RSK2-IN-3 Inhibitor / Unkown
HY-RS12254 RPS6KA3 Human Pre-designed siRNA Set A / Unkown
HY-RS12255 Rps6ka3 Mouse Pre-designed siRNA Set A / Unkown
HY-RS12256 Rps6ka3 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rps6ka3 NCBI NCBI:6197