Rps6ka3 - ribosomal protein S6 kinase polypeptide 3 Gene

Also Known as Rsk2; MPK-9; p90RSK3; pp90RSK2; MAPKAPK-1b; S6K-alpha3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 110651

About Rps6ka3

Chromosome X: 157,993,303-158,151,240 forward strand.GRCm39:CM001013.3

This gene has 9 transcripts (splice variants), 252 orthologues, 7 paralogues and is associated with 44 phenotypes. Ubiquitous expression in subcutaneous fat pad adult (RPKM 6.8), genital fat pad adult (RPKM 5.9) and 26 other tissues.

Summary

Enables protein kinase binding activity and protein serine/threonine kinase activity. Involved in response to lipopolysaccharide and Toll-like Receptor signaling pathway. Predicted to be located in cytosol and nucleolus. Predicted to be active in cytoplasm and nucleoplasm. Is expressed in several structures, including alimentary system; blastocyst; branchial arch; central nervous system; and eye. Used to study Coffin-Lowry syndrome. Human ortholog(s) of this gene implicated in Coffin-Lowry syndrome; intellectual disability; and non-syndromic X-linked intellectual disability 19. Orthologous to human RPS6KA3 (ribosomal protein S6 kinase A3). [provided by Alliance of Genome Resources, Apr 2022]

Rps6ka3 Products (2)

mRNA Protein Name
NM_148945.2 NP_683747.1 ribosomal protein S6 kinase alpha-3 isoform 1
NM_001346675.1 NP_001333604.1 ribosomal protein S6 kinase alpha-3 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15109498 MGI
enables protein kinase binding IPI
IPI: Inferred from physical interaction
17906627 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
12016217 MGI
Biological Process GO Annotation Evidence References Source
involved in response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
17906627 MGI
involved in toll-like receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
17906627 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Rps6ka3 Protein Structure

STKc_RSK_N

STKc_RSK_N: cd05582 (71 - 387)

STKc_RSK2_C

STKc_RSK2_C: cd14176 (401 - 739)

  • 0
  • 200
  • 400
  • 600
  • 740 a.a.
Protein Preferred Names Protein Names

ribosomal protein S6 kinase alpha-3

  • 90 kDa ribosomal protein S6 kinase 3

  • MAP kinase-activated protein kinase 1b

  • MAPK-activated protein kinase 1b

  • MAPKAP kinase 1b

  • ribosomal protein S6 kinase 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148061 DB1113 99.86% Unkown
HY-148063 DB0614 99.92% Unkown
HY-150643 RSK2-IN-2 Inhibitor / Unkown
HY-150717 RSK2-IN-3 Inhibitor / Unkown
HY-RS12254 RPS6KA3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12255 Rps6ka3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12256 Rps6ka3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rps6ka3 NCBI NCBI:6197