Chrna3 - cholinergic receptor, nicotinic, alpha polypeptide 3 Gene

Also Known as (a)3; Acra3; Acra-3; A730007P14Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 110834

Summary

Enables acetylcholine-gated cation-selective channel activity. Acts upstream of or within several processes, including activation of transmembrane receptor protein tyrosine kinase activity; behavioral response to nicotine; and chemical synaptic transmission. Is integral component of postsynaptic specialization membrane. Part of acetylcholine-gated channel complex. Is active in cholinergic synapse. Is expressed in several structures, including central nervous system; gut; myenteric nerve plexus; paravertebral ganglion; and retina. Human ortholog(s) of this gene implicated in lung Cancer. Orthologous to human CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit). [provided by Alliance of Genome Resources, Apr 2022]

Chrna3 Products (1)

mRNA	Protein	Name
NM_145129.3	NP_660111.3	neuronal acetylcholine receptor subunit alpha-3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables acetylcholine-gated monoatomic cation-selective channel activity	IMP IMP: Inferred from mutant phenotype	11923417	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	19474315	MGI
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IDA IDA: Inferred from direct assay	16162937	MGI
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IMP IMP: Inferred from mutant phenotype	16162937	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within activation of transmembrane receptor protein tyrosine kinase activity	IMP IMP: Inferred from mutant phenotype	16162937	MGI
acts upstream of or within behavioral response to nicotine	IMP IMP: Inferred from mutant phenotype	15275829	MGI
acts upstream of or within excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	16162937	MGI
acts upstream of or within locomotory behavior	IMP IMP: Inferred from mutant phenotype	15275829	MGI
acts upstream of or within regulation of acetylcholine secretion, neurotransmission	IMP IMP: Inferred from mutant phenotype	16162937	MGI
acts upstream of or within regulation of dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	11027228	MGI
acts upstream of or within regulation of membrane potential	IMP IMP: Inferred from mutant phenotype	10318955	MGI
acts upstream of or within regulation of muscle contraction	IMP IMP: Inferred from mutant phenotype	10318955	MGI
acts upstream of or within regulation of smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	10318955	MGI
acts upstream of or within synaptic transmission involved in micturition	IMP IMP: Inferred from mutant phenotype	10771006	MGI
acts upstream of or within synaptic transmission, cholinergic	IMP IMP: Inferred from mutant phenotype	16162937	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of acetylcholine-gated channel complex	IPI IPI: Inferred from physical interaction	17434683	MGI
is active in cholinergic synapse	IDA IDA: Inferred from direct assay	12079404	MGI
is active in cholinergic synapse	IMP IMP: Inferred from mutant phenotype	16162937	MGI
is active in postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	12079404	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
neuronal acetylcholine receptor subunit alpha-3	alpha 3 neuronal nicotinic acetylcholine receptor, alpha 3 subunit

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02668	CHRNA3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20143	Chrna3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26647	Chrna3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Chrna3	NCBI	NCBI:1136