Gabra5 - gamma-aminobutyric acid (GABA) A receptor, subunit alpha 5 Gene

Also Known as A230018I05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 110886

Summary

Predicted to enable GABA Receptor binding activity and extracellular ligand-gated ion channel activity. Predicted to contribute to GABA-A receptor activity; benzodiazepine receptor activity; and Chloride Channel activity. Involved in several processes, including inner ear development; innervation; and sensory perception of sound. Acts upstream of or within associative learning and behavioral fear response. Located in cell body and dendrite. Is expressed in brain. Human ortholog(s) of this gene implicated in bipolar disorder; developmental and epileptic encephalopathy 79; and mental depression. Orthologous to human GABRA5 (gamma-aminobutyric acid type A receptor subunit alpha5). [provided by Alliance of Genome Resources, Apr 2022]

Gabra5 Products (3)

mRNA Protein Name
NM_001362161.1 NP_001349090.1 gamma-aminobutyric acid receptor subunit alpha-5 precursor
NM_001362162.1 NP_001349091.1 gamma-aminobutyric acid receptor subunit alpha-5 precursor
NM_176942.4 NP_795916.1 gamma-aminobutyric acid receptor subunit alpha-5 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GABA-A receptor activity IMP
IMP: Inferred from mutant phenotype
14993607 MGI
enables GABA-gated chloride ion channel activity IMP
IMP: Inferred from mutant phenotype
14993607 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16467845 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within associative learning IMP
IMP: Inferred from mutant phenotype
12084936 MGI
acts upstream of or within behavioral fear response IMP
IMP: Inferred from mutant phenotype
12084936 MGI
involved in cochlea development IMP
IMP: Inferred from mutant phenotype
17021187 MGI
involved in inner ear receptor cell development IMP
IMP: Inferred from mutant phenotype
17021187 MGI
involved in innervation IMP
IMP: Inferred from mutant phenotype
17021187 MGI
involved in neuron development IMP
IMP: Inferred from mutant phenotype
17021187 MGI
Cellular Component GO Annotation Evidence References Source
located in cell body IDA
IDA: Inferred from direct assay
9682826 MGI
located in dendrite IDA
IDA: Inferred from direct assay
9682826 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

gamma-aminobutyric acid receptor subunit alpha-5

  • GABA(A) receptor subunit alpha-5

  • ligand-gated ion channel subunit

Gabra5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Gabra5 Q8BHJ7 Rdx Rattus norvegicus Q5WQV5
Pull Down
16467845
Cross
Gabra5 Q8BHJ7 Rdx Rattus norvegicus Q5WQV5
Y2H
16467845
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05213 GABRA5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-186006 GABRA5 modulator-1 / Unkown
HY-RS21856 Gabra5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28373 Gabra5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gabra5 NCBI NCBI:2558