KLHL2 - kelch like family member 2 Gene
Also Known as MAV; MAYVEN; ABP-KELCH
Species: Homo sapiens
About KLHL2
This gene has 10 transcripts (splice variants), 196 orthologues and 54 paralogues. Ubiquitous expression in brain (RPKM 27.3), esophagus (RPKM 8.4) and 24 other tissues.
Summary
Enables actin binding activity and identical protein binding activity. Predicted to be involved in protein ubiquitination. Located in actin Cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]
KLHL2 Products (5)
| mRNA | Protein | Name |
|---|---|---|
| NM_001161521.1 | NP_001154993.1 | kelch-like protein 2 isoform 2 |
| NM_001161522.1 | NP_001154994.1 | kelch-like protein 2 isoform 3 |
| NM_001331023.2 | NP_001317952.1 | kelch-like protein 2 isoform 4 |
| NM_001331024.2 | NP_001317953.1 | kelch-like protein 2 isoform 5 |
| NM_007246.4 | NP_009177.3 | kelch-like protein 2 isoform 1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables actin binding |
IDA
IDA: Inferred from direct assay
|
10397770 | GOA |
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
25416956 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
16189514 | GOA |
| enables ubiquitin-like ligase-substrate adaptor activity |
IDA
IDA: Inferred from direct assay
|
23838290 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in actin cytoskeleton |
IDA
IDA: Inferred from direct assay
|
10397770 | GOA |
KLHL2 Protein Structure
BTB: BTB/POZ domain (46 - 152)
BACK: BTB And C-terminal Kelch (158 - 260)
Kelch_1: Kelch motif (309 - 340)
Kelch_1: Kelch motif (342 - 387)
Kelch_1: Kelch motif (389 - 434)
Kelch_1: Kelch motif (436 - 483)
Kelch_1: Kelch motif (485 - 530)
Kelch_1: Kelch motif (533 - 576)
- 0
- 100
- 200
- 300
- 400
- 500
- 593 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
kelch-like protein 2 |
|
KLHL2 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
KLHL2 | O95198 | UBE2I | Homo sapiens | Q7KZS0 | 32296183 | |
|
Intra
|
KLHL2 | O95198 | UBE2I | Homo sapiens | Q7KZS0 | 32296183 | |
|
Intra
|
KLHL2 | O95198 | UBE2I | Homo sapiens | Q7KZS0 | 32296183 | |
|
Intra
|
KLHL2 | O95198 | BCAM | Homo sapiens | P50895 | 25416956 | |
|
Intra
|
KLHL2 | O95198 | BCAM | Homo sapiens | P50895 | 25416956 | |
|
Intra
|
KLHL2 | O95198 | UBE2C | Homo sapiens | Q5TZN3 | 25416956 | |
|
Intra
|
KLHL2 | O95198 | CCDC43 | Homo sapiens | Q86WV7 | 25416956 | |
|
Intra
|
KLHL2 | O95198 | CCDC43 | Homo sapiens | Q86WV7 | 25416956 | |
|
Intra
|
KLHL2 | O95198 | ZNF114 | Homo sapiens | Q8NC26 | 32296183 | |
|
Intra
|
KLHL2 | O95198 | ZNF114 | Homo sapiens | Q8NC26 | 25416956 | |
|
Intra
|
KLHL2 | O95198 | ZNF114 | Homo sapiens | Q8NC26 | 31515488 | |
|
Intra
|
KLHL2 | O95198 | ZNF114 | Homo sapiens | Q8NC26 | 25416956 | |
|
Intra
|
KLHL2 | O95198 | TMA16 | Homo sapiens | Q96EY4 | 25416956 | |
|
Intra
|
KLHL2 | O95198 | TMA16 | Homo sapiens | Q96EY4 | 32296183 | |
|
Intra
|
KLHL2 | O95198 | TMA16 | Homo sapiens | Q96EY4 | 25416956 | |
|
Intra
|
KLHL2 | O95198 | MFAP1 | Homo sapiens | P55081 | 32296183 | |
|
Intra
|
KLHL2 | O95198 | PADI6 | Homo sapiens | Q6TGC4 | 32296183 | |
|
Intra
|
KLHL2 | O95198 | CIMIP1 | Homo sapiens | Q9H1P6 | 32296183 | |
|
Intra
|
KLHL2 | O95198 | PIBF1 | Homo sapiens | Q4G0R1 | 32296183 | |
|
Intra
|
KLHL2 | O95198 | TXNDC12 | Homo sapiens | O95881 | 25416956 | |
|
Intra
|
KLHL2 | O95198 | TXNDC12 | Homo sapiens | O95881 | 25416956 | |
|
Intra
|
KLHL2 | O95198 | CDC37 | Homo sapiens | Q16543 | 32296183 | |
|
Intra
|
KLHL2 | O95198 | BYSL | Homo sapiens | Q13895 | 32296183 | |
|
Intra
|
KLHL2 | O95198 | CWC22 | Homo sapiens | Q9HCG8 | 32296183 | |
|
Intra
|
KLHL2 | O95198 | NAP1L2 | Homo sapiens | Q9ULW6 | 32296183 | |
|
Intra
|
KLHL2 | O95198 | CUL3 | Homo sapiens | Q13618 | 30190310 | |
|
Intra
|
KLHL2 | O95198 | CUL3 | Homo sapiens | Q13618 | 25416956 | |
|
Intra
|
KLHL2 | O95198 | POLR3C | Homo sapiens | Q9BUI4 | 32296183 | |
|
Intra
|
KLHL2 | O95198 | SDCBP | Homo sapiens | O00560 | 25416956 | |
|
Intra
|
KLHL2 | O95198 | KLHL12 | Homo sapiens | Q53G59 | 32296183 | |
|
Intra
|
KLHL2 | O95198 | KLHL12 | Homo sapiens | Q53G59 | 32296183 | |
|
Intra
|
KLHL2 | O95198 | KLHL12 | Homo sapiens | Q53G59 | 16189514 | |
|
Intra
|
KLHL2 | O95198 | KLHL12 | Homo sapiens | Q53G59 | 32296183 | |
|
Intra
|
KLHL2 | O95198 | KLHL12 | Homo sapiens | Q53G59 | 33961781 | |
|
Intra
|
KLHL2 | O95198 | KLHL12 | Homo sapiens | Q53G59 | 30190310 | |
|
Intra
|
KLHL2 | O95198 | NTAQ1 | Homo sapiens | Q96HA8 | 32296183 | |
|
Intra
|
KLHL2 | O95198 | ELOA | Homo sapiens | Q14241 | 32296183 | |
|
Intra
|
KLHL2 | O95198 | CLK2 | Homo sapiens | P49760 | 32296183 | |
|
Intra
|
KLHL2 | O95198 | CLK2 | Homo sapiens | P49760 | 25416956 | |
|
Intra
|
KLHL2 | O95198 | KEAP1 | Homo sapiens | Q14145 | 32296183 | |
|
Intra
|
KLHL2 | O95198 | KEAP1 | Homo sapiens | Q14145 | 33961781 | |
|
Intra
|
KLHL2 | O95198 | KEAP1 | Homo sapiens | Q14145 | 30190310 | |
|
Intra
|
KLHL2 | O95198 | KEAP1 | Homo sapiens | Q14145 | 32296183 | |
|
Intra
|
KLHL2 | O95198 | KEAP1 | Homo sapiens | Q14145 | 30190310 | |
|
Intra
|
KLHL2 | O95198 | KEAP1 | Homo sapiens | Q14145 | 32296183 | |
|
Intra
|
KLHL2 | O95198 | KLHL3 | Homo sapiens | Q9UH77 | 33961781 | |
|
Intra
|
KLHL2 | O95198 | KLHL3 | Homo sapiens | Q9UH77 | 32296183 | |
|
Intra
|
KLHL2 | O95198 | KLHL3 | Homo sapiens | Q9UH77 | 32296183 | |
|
Intra
|
KLHL2 | O95198 | KLHL3 | Homo sapiens | Q9UH77 | 32296183 | |
|
Intra
|
KLHL2 | O95198 | TRIM50 | Homo sapiens | Q86XT4 | 32296183 |
Recombinant KLHL2 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P76470 | KLHL2 Protein, Human (His) | O95198-1 (M1-P306) | ≥ 90%, as determined by reducing SDS-PAGE. |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Variola Minor |
|
|
| Mixed Malaria |
|
|
| Monkeypox |
|
|
| Plasmodium Ovale Malaria |
|
|
| Nemaline Myopathy 6 |
|
|
| Crisponi/Cold-Induced Sweating Syndrome 1 |
|
|
| Plasmodium Vivax Malaria |
|
|
| Nemaline Myopathy 8 |
|
|
| Milker'S Nodule |
|
|
| Variola Major |
|
|
| Nemaline Myopathy 3 |
|
|
| Retinitis Pigmentosa 42 |
|
|
| Intraorbital Meningioma |
|
|
| Methylmalonic Aciduria And Homocystinuria, Cblx Type |
|
|
| Giant Axonal Neuropathy 1, Autosomal Recessive |
|
|
| Arts Syndrome |
|
|
| Contagious Pustular Dermatitis |
|
|
| Cold-Induced Sweating Syndrome |
|
|
| Parasitic Protozoa Infectious Disease |
|
|
| Cowpox |
|
|
| Cerebral Amyloid Angiopathy, Itm2b-Related, 1 |
|
|
| Neurilemmomatosis |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | KLHL2 | MGD | MGI:1924363 |
| Macaca mulatta | KLHL2 | VGNC | VGNC:74185 |
| Canis familiaris | KLHL2 | VGNC | VGNC:42454 |
| Bos taurus | KLHL2 | VGNC | VGNC:30648 |
| Felis catus | KLHL2 | VGNC | VGNC:67958 |
| Rattus norvegicus | KLHL2 | RGD | RGD:1306388 |
| Others | KLHL2 | NCBI |