SIGLEC11 - sialic acid binding Ig like lectin 11 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 114132

About SIGLEC11

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,948,985-49,961,172 (from NCBI)

This gene has 3 transcripts (splice variants), 133 orthologues and 16 paralogues. Biased expression in ovary (RPKM 40.7), spleen (RPKM 13.8) and 1 other tissue.

Summary

This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. This family member mediates anti-inflammatory and immunosuppressive signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

SIGLEC11 Products (2)

mRNA Protein Name
NM_001135163.1 NP_001128635.1 sialic acid-binding Ig-like lectin 11 isoform 2 precursor
NM_052884.3 NP_443116.2 sialic acid-binding Ig-like lectin 11 isoform 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables phosphatase binding IPI
IPI: Inferred from physical interaction
11986327 GOA
enables sialic acid binding IDA
IDA: Inferred from direct assay
11986327 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIGLEC11 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (37 - 136)

C2-set_2

C2-set_2: CD80-like C2-set immunoglobulin domain (160 - 236)

I-set

I-set: Immunoglobulin I-set domain (275 - 351)

ig

ig: Immunoglobulin domain (384 - 438)

  • 0
  • 200
  • 400
  • 600
  • 698 a.a.
Protein Preferred Names Protein Names

sialic acid-binding Ig-like lectin 11

  • siglec-11

Recombinant SIGLEC11 Proteins

Cat. No. Product Name Accession Purity
HY-P79127 Siglec-11 Protein, Human (E84A, K145Q, CHO, hFc) AAK72907 (N17-H543, E84A, K145Q) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Alzheimer Disease 2

  • AD2

  • Alzheimer Disease Associated With Apoe4

  • Alzheimer'S Disease 2

  • Alzheimer Disease-2

  • Alzheimer Disease 2, Late-Onset

  • Alzheimer Disease 2, Late Onset

  • Late-Onset Alzheimer Disease

  • Alzheimer Disease, Type 2

  • Alzheimer Disease, Late Onset
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12899 SIGLEC11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SIGLEC11 MGD MGI:2443630
Others SIGLEC11 NCBI