CYP27B1 - Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 Gene

Also Known as Cyp40

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 114700

Summary

Enables calcidiol 1-monooxygenase activity. Involved in several processes, including negative regulation of bone trabecula formation; positive regulation of parathyroid hormone secretion; and vitamin D catabolic process. Located in mitochondrion. Used to study Wilson disease; acute kidney failure; nephrosis; and vitamin D-dependent rickets type 1A. Human ortholog(s) of this gene implicated in hepatitis B; obesity; rickets; type 1 diabetes mellitus; and vitamin D-dependent rickets type 1A. Orthologous to human CYP27B1 (Cytochrome P450 family 27 subfamily B member 1). [provided by Alliance of Genome Resources, Apr 2022]

CYP27B1 Products (1)

mRNA Protein Name
NM_053763.1 NP_446215.1 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Verweise Source
enables calcidiol 1-monooxygenase activity IDA
IDA: Inferred from direct assay
9333115 RGD
Biological Process GO Annotation Evidence Verweise Source
involved in lactation IEP
IEP: Inferred from expression pattern
8333523 RGD
involved in negative regulation of bone trabecula formation IMP
IMP: Inferred from mutant phenotype
32231239 RGD
involved in negative regulation of ossification IMP
IMP: Inferred from mutant phenotype
32231239 RGD
involved in positive regulation of parathyroid hormone secretion IMP
IMP: Inferred from mutant phenotype
32231239 RGD
involved in response to cAMP IDA
IDA: Inferred from direct assay
6282936 RGD
involved in response to calcium ion IEP
IEP: Inferred from expression pattern
8333523 RGD
involved in response to copper ion IDA
IDA: Inferred from direct assay
3348368 RGD
involved in response to insulin IDA
IDA: Inferred from direct assay
3295473 RGD
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
10393981 RGD
involved in response to prostaglandin E IDA
IDA: Inferred from direct assay
3937586 RGD
involved in response to vitamin D IDA
IDA: Inferred from direct assay
3000565 RGD
involved in response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
3937586 RGD
involved in vitamin D catabolic process IDA
IDA: Inferred from direct assay
9333115 RGD
involved in vitamin D metabolic process IDA
IDA: Inferred from direct assay
9371776 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial

  • 25-OHD-1 alpha-hydroxylase

  • 25-hydroxyvitamin D(3) 1-alpha-hydroxylase

  • 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial-like

  • P450C1 alpha

  • P450VD1-alpha

  • VD3 1A hydroxylase

  • calcidiol 1-monooxygenase

  • cytochrome P450 subfamily XXVIIB (25-hydroxyvi

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-173191 SK-124 Inhibitor 95.0% Unkown
HY-154825 20-Hydroxyvitamin D3 ≥98.0% Unkown
HY-RS03451 CYP27B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16287 Cyp27b1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS25766 Cyp27b1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens CYP27B1 NCBI NCBI:1594