C1QTNF3 - C1q and TNF related 3 Gene

Also Known as CORS; CORCS; CTRP3; CORS26; C1ATNF3; CORS-26

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 114899

About C1QTNF3

Cytogenetic location: 5p13.2 Genomic coordinates (GRCh38): 5:34,017,858-34,244,724 (from NCBI)

This gene has 6 transcripts (splice variants), 117 orthologues and 23 paralogues. Broad expression in esophagus (RPKM 12.4), urinary bladder (RPKM 10.0) and 21 other tissues.

Summary

Enables identical protein binding activity. Involved in several processes, including cellular triglyceride homeostasis; negative regulation of NIK/NF-kappaB signaling; and regulation of cytokine production. Acts upstream of or within negative regulation of gluconeogenesis. Located in extracellular exosome and membrane. [provided by Alliance of Genome Resources, Apr 2022]

C1QTNF3 Products (2)

mRNA	Protein	Name
NM_030945.4	NP_112207.1	complement C1q tumor necrosis factor-related protein 3 isoform a precursor
NM_181435.6	NP_852100.3	complement C1q tumor necrosis factor-related protein 3 isoform b precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	16213490	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20952387	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in fat cell differentiation	IEP IEP: Inferred from expression pattern	20739398	GOA
involved in intracellular triglyceride homeostasis	IDA IDA: Inferred from direct assay	20739398	GOA
involved in negative regulation of gene expression	IDA IDA: Inferred from direct assay	20952387	GOA
acts upstream of or within negative regulation of gluconeogenesis	IDA IDA: Inferred from direct assay	20952387	GOA
involved in negative regulation of gluconeogenesis	IDA IDA: Inferred from direct assay	20952387	GOA
involved in negative regulation of inflammatory response	IDA IDA: Inferred from direct assay	16213490	GOA
involved in negative regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	16213490	GOA
involved in negative regulation of monocyte chemotactic protein-1 production	IDA IDA: Inferred from direct assay	20739398	GOA
involved in negative regulation of non-canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	16213490	GOA
involved in positive regulation of adiponectin secretion	IDA IDA: Inferred from direct assay	18421280	GOA
involved in positive regulation of cytokine production	IDA IDA: Inferred from direct assay	18421280	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

C1QTNF3 Protein Structure

Collagen

C1q

0
100
200
246 a.a.

Protein Preferred Names	Protein Names
complement C1q tumor necrosis factor-related protein 3	C1q and tumor necrosis factor related protein 3

C1QTNF3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	C1QTNF3	Q9BXJ4	COLGALT2	Homo sapiens	Q8IYK4	Anti Tag CoIP	33961781
Intra	C1QTNF3	Q9BXJ4	COLGALT2	Homo sapiens	Q8IYK4	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant C1QTNF3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71648	C1QTNF3/CTRP3 Protein, Human (His)	Q9BXJ4-1 (Q23-K246)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Cataract 31, Multiple Types	Cataract, Posterior Polar, 3 Ctpp3 Cataract 31 Multiple Types CTRCT31 Cpp3 Posterior Polar Cataract 3 Cataract, Type 31, Multiple Types
Chromosome 5p13 Duplication Syndrome	5p13 Microduplication Syndrome Trisomy 5p13 Dup(5)(P13)

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS18206	C1qtnf3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01729	C1QTNF3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24683	C1qtnf3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	C1QTNF3	MGD	MGI:1932136
Rattus norvegicus	C1QTNF3	RGD	RGD:1305010
Others	C1QTNF3	NCBI