FBXO32 - F-box protein 32 Gene

Also Known as Fbx32; MAFbx

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 114907

About FBXO32

Cytogenetic location: 8q24.13 Genomic coordinates (GRCh38): 8:123,497,889-123,541,206 (from NCBI)

This gene has 6 transcripts (splice variants), 205 orthologues and 1 paralogue. Broad expression in endometrium (RPKM 28.7), heart (RPKM 22.1) and 18 other tissues.

Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein Ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]

FBXO32 Products (3)

mRNA Protein Name
NM_001242463.2 NP_001229392.1 F-box only protein 32 isoform 3
NM_058229.4 NP_478136.1 F-box only protein 32 isoform 1
NM_148177.3 NP_680482.1 F-box only protein 32 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18354498 GOA
Biological Process GO Annotation Evidence References Source
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
26753747 GOA
Cellular Component GO Annotation Evidence References Source
part of SCF ubiquitin ligase complex IDA
IDA: Inferred from direct assay
26753747 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
26768247 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

F-box only protein 32

  • atrogin 1

FBXO32 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FBXO32 Q969P5 EIF3F Homo sapiens O00303
IF
18354498
Intra
FBXO32 Q969P5 EIF3F Homo sapiens O00303
Anti Tag CoIP
18354498
Intra
FBXO32 Q969P5 EIF3F Homo sapiens O00303
Pull Down
18354498
Cross: Cross-species interaction Intra: Intraspecies interaction

FBXO32 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81082 Fbx32 Antibody (YA919) WB; ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Muscle Hypertrophy

  • MSLHP

  • Hypertrophy

  • Hypertrophy, Muscle
Dilated Cardiomyopathy

  • Familial Dilated Cardiomyopathy

  • Primary Dilated Cardiomyopathy

  • Idiopathic Dilated Cardiomyopathy

  • Congestive Cardiomyopathy

  • Idiopathic Dilation Cardiomyopathy

  • Primary Familial Dilated Cardiomyopathy

  • Cardiomyopathy, Dilated

  • DCM

  • Cardiomyopathy, Familial Dilated

  • Dilated Cardiomyopathy, Familial

  • Hypokinetic Dilated Cardiomyopathy, Familial

  • Familial Idiopathic Cardiomyopathy

  • Fdc

  • Cardiomyopathy, Familial Idiopathic

  • Idiopathic Cardiomegaly

  • Dilated Congestive Cardiomyopathy

  • Chronic Dilated Cardiomyopathy

  • Ccm - [Congestive Cardiomyopathy]

  • Cocm - [Congestive Cardiomyopathy]

  • Dcm - [Dilated Cardiomyopathy]

  • Dilated-Hypokinetic Cardiomyopathy

  • Congestive Idiopathic Cardiomyopathy

  • Primary Idiopathic Dilated Cardiomyopathy
Muscle Tissue Disease
Acquired Immunodeficiency Syndrome

  • Acquired Immune Deficiency Syndrome

  • AIDS

  • Acquired Immune Deficiency

  • Acquired Immunodeficiency

  • Acquired Immunodeficiency Due To Protein Loss
Muscular Disease
Muscular Dystrophy

  • Muscular Dystrophies

  • Congenital Md

  • Congenital Muscular Dystrophy

  • Cmd

  • Mdc

  • Dystrophy, Muscular

  • Gower'S Muscular Dystrophy

  • Progressive Musclular Dystrophy

  • Pseudohypertrophic Atrophy

  • Pseudohypertrophic Muscle Paralysis

  • Pseudohypertrophic Muscular Atrophy

  • Pseudohypertrophic Muscular Dystrophy

  • Pseudohypertrophic Paralysis

  • Pseudomuscular Hypertrophy
Ullrich Congenital Muscular Dystrophy 1

  • Ullrich Congenital Muscular Dystrophy

  • Ullrich Disease

  • Ucmd

  • Ullrich Scleroatonic Muscular Dystrophy

  • Scleroatonic Muscular Dystrophy

  • UCMD1

  • Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 22

  • Lgmdr22

  • Muscular Dystrophy, Scleroatonic

  • Late Onset Scleroatonic Familial Myopathy

  • Congenital Muscular Dystrophy, Ullrich Type
Myopathy

  • Muscular Diseases

  • Myopathies
Neuromuscular Disease

  • Neuromuscular Diseases

  • Neuromuscular Disorders

  • Neuromuscular Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04804 FBXO32 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20156 Fbxo32 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26660 Fbxo32 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris FBXO32 VGNC VGNC:40774
Bos taurus FBXO32 VGNC VGNC:28905
Mus musculus FBXO32 MGD MGI:1914981
Macaca mulatta FBXO32 VGNC VGNC:72517
Rattus norvegicus FBXO32 RGD RGD:620373
Felis catus FBXO32 VGNC VGNC:62186
Others FBXO32 NCBI