Eif4ebp1 - eukaryotic translation initiation factor 4E binding protein 1 Gene

Also Known as PHAS-I

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 116636

Summary

Enables eukaryotic initiation factor 4E binding activity and protein Phosphatase 2A binding activity. Involved in several processes, including response to amino acid starvation; response to ethanol; and response to ischemia. Located in cytoplasm and nucleus. Part of protein-containing complex. Is active in glutamatergic synapse and postsynaptic cytosol. Used to study tuberous sclerosis. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human EIF4EBP1 (eukaryotic translation initiation factor 4E binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Eif4ebp1 Products (1)

mRNA Protein Name
NM_053857.2 NP_446309.1 eukaryotic translation initiation factor 4E-binding protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables eukaryotic initiation factor 4E binding IPI
IPI: Inferred from physical interaction
18952566 RGD
enables protein phosphatase 2A binding IPI
IPI: Inferred from physical interaction
16899564 RGD
enables translation initiation factor binding IPI
IPI: Inferred from physical interaction
11865047 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to hypoxia IDA
IDA: Inferred from direct assay
10100614 RGD
involved in lung development IEP
IEP: Inferred from expression pattern
18952566 RGD
involved in negative regulation of protein-containing complex assembly IMP
IMP: Inferred from mutant phenotype
11865047 RGD
involved in negative regulation of translational initiation IMP
IMP: Inferred from mutant phenotype
11865047 RGD
involved in response to amino acid starvation IDA
IDA: Inferred from direct assay
11500297 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
15388509 RGD
involved in response to ischemia IEP
IEP: Inferred from expression pattern
20736160 RGD
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
11756682 RGD
is active in postsynaptic cytosol IDA
IDA: Inferred from direct assay
11756682 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
18952566 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

eukaryotic translation initiation factor 4E-binding protein 1

  • 4E-BP1

  • eIF4E-binding protein 1

  • phosphorylated heat- and acid-stable protein regulated by insulin 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04277 EIF4EBP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20227 Eif4ebp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26734 Eif4ebp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Eif4ebp1 NCBI NCBI:1978