EIF4EBP1 - eukaryotic translation initiation factor 4E binding protein 1 Gene
Also Known as BP-1; 4EBP1; 4E-BP1; PHAS-I
Species: Homo sapiens
About EIF4EBP1
This gene has 2 transcripts (splice variants), 245 orthologues and 2 paralogues. Ubiquitous expression in salivary gland (RPKM 30.3), fat (RPKM 26.3) and 25 other tissues.
Summary
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and Insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]
EIF4EBP1 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_004095.4 | NP_004086.1 | eukaryotic translation initiation factor 4E-binding protein 1 |
| Molecular Function GO Annotation | Evidence | Références | Source |
|---|---|---|---|
| enables eukaryotic initiation factor 4E binding |
IDA
IDA: Inferred from direct assay
|
23814182 | GOA |
| enables eukaryotic initiation factor 4E binding |
IPI
IPI: Inferred from physical interaction
|
38177902 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
7651417 | GOA |
| enables translation initiation factor binding |
EXP
EXP: Inferred from Experiment
|
9453748 | GOA |
| enables translation initiation factor binding |
IPI
IPI: Inferred from physical interaction
|
17368478 | GOA |
| enables translation repressor activity |
IDA
IDA: Inferred from direct assay
|
22578813 | GOA |
| Biological Process GO Annotation | Evidence | Références | Source |
|---|---|---|---|
| involved in G1/S transition of mitotic cell cycle |
IMP
IMP: Inferred from mutant phenotype
|
14673156 | GOA |
| involved in TOR signaling |
IDA
IDA: Inferred from direct assay
|
12150926 | GOA |
| involved in negative regulation of translation |
IDA
IDA: Inferred from direct assay
|
9453748 | GOA |
| involved in negative regulation of translational initiation |
IDA
IDA: Inferred from direct assay
|
22578813 | GOA |
| involved in positive regulation of mitotic cell cycle |
IMP
IMP: Inferred from mutant phenotype
|
14673156 | GOA |
| Cellular Component GO Annotation | Evidence | Références | Source |
|---|---|---|---|
| located in cytosol |
IDA
IDA: Inferred from direct assay
|
23814182 | GOA |
EIF4EBP1 Protein Structure
eIF_4EBP: Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) (6 - 118)
- 0
- 100
- 118 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
eukaryotic translation initiation factor 4E-binding protein 1 |
|
EIF4EBP1 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | Références |
|---|---|---|---|---|---|---|---|
|
Intra
|
EIF4EBP1 | Q13541 | REL | Homo sapiens | Q04864-2 | 32296183 | |
|
Intra
|
EIF4EBP1 | Q13541 | REL | Homo sapiens | Q04864-2 | 32296183 | |
|
Intra
|
EIF4EBP1 | Q13541 | LMO2 | Homo sapiens | P25791-3 | 32296183 | |
|
Intra
|
EIF4EBP1 | Q13541 | LMO2 | Homo sapiens | P25791-3 | 32296183 | |
|
Intra
|
EIF4EBP1 | Q13541 | POU6F2 | Homo sapiens | P78424 | 32296183 | |
|
Intra
|
EIF4EBP1 | Q13541 | POU6F2 | Homo sapiens | P78424 | 32296183 | |
|
Intra
|
EIF4EBP1 | Q13541 | RPTOR | Homo sapiens | Q8N122 | 12150926 | |
|
Intra
|
EIF4EBP1 | Q13541 | RPTOR | Homo sapiens | Q8N122 | 12150926 | |
|
Cross
|
EIF4EBP1 | Q13541 | Mtor | Mus musculus | Q9JLN9 | 12150926 | |
|
Cross
|
EIF4EBP1 | Q13541 | Mtor | Mus musculus | Q9JLN9 | 12150926 | |
|
Intra
|
EIF4EBP1 | Q13541 | EIF4E1B | Homo sapiens | A6NMX2 | 33961781 | |
|
Intra
|
EIF4EBP1 | Q13541 | EIF4E1B | Homo sapiens | A6NMX2 | 32296183 | |
|
Intra
|
EIF4EBP1 | Q13541 | EIF4E1B | Homo sapiens | A6NMX2 | 32296183 | |
|
Intra
|
EIF4EBP1 | Q13541 | MEOX1 | Homo sapiens | P50221 | 32296183 | |
|
Intra
|
EIF4EBP1 | Q13541 | MEOX1 | Homo sapiens | P50221 | 32296183 | |
|
Intra
|
EIF4EBP1 | Q13541 | EIF4E2 | Homo sapiens | O60573-1 | 28698298 | |
|
Intra
|
EIF4EBP1 | Q13541 | EIF4E | Homo sapiens | P06730-1 | 28698298 | |
|
Intra
|
EIF4EBP1 | Q13541 | EIF4E2 | Homo sapiens | O60573 | 15094042 | |
|
Intra
|
EIF4EBP1 | Q13541 | EIF4E2 | Homo sapiens | O60573 | 33961781 | |
|
Intra
|
EIF4EBP1 | Q13541 | AGO2 | Homo sapiens | Q9UKV8 | 20671708 | |
|
Intra
|
EIF4EBP1 | Q13541 | TCF4 | Homo sapiens | P15884 | 25416956 | |
|
Intra
|
EIF4EBP1 | Q13541 | TCF4 | Homo sapiens | P15884 | 25416956 | |
|
Intra
|
EIF4EBP1 | Q13541 | ZNF655 | Homo sapiens | Q8N720 | 32296183 | |
|
Intra
|
EIF4EBP1 | Q13541 | ZNF655 | Homo sapiens | Q8N720 | 32296183 | |
|
Intra
|
EIF4EBP1 | Q13541 | ZNF655 | Homo sapiens | Q8N720 | 32296183 | |
|
Intra
|
EIF4EBP1 | Q13541 | EIF4E | Homo sapiens | P06730 | 16504179 | |
|
Intra
|
EIF4EBP1 | Q13541 | EIF4E | Homo sapiens | P06730 | 24211447 | |
|
Intra
|
EIF4EBP1 | Q13541 | EIF4E | Homo sapiens | P06730 | 20880835 | |
|
Intra
|
EIF4EBP1 | Q13541 | EIF4E | Homo sapiens | P06730 | 17353931 | |
|
Intra
|
EIF4EBP1 | Q13541 | EIF4E | Homo sapiens | P06730 | 22678294 | |
|
Intra
|
EIF4EBP1 | Q13541 | EIF4E | Homo sapiens | P06730 | 20880835 | |
|
Intra
|
EIF4EBP1 | Q13541 | DDIT4L | Homo sapiens | Q96D03 | 32296183 | |
|
Intra
|
EIF4EBP1 | Q13541 | DDIT4L | Homo sapiens | Q96D03 | 32296183 | |
|
Intra
|
EIF4EBP1 | Q13541 | DDIT4L | Homo sapiens | Q96D03 | 32296183 | |
|
Intra
|
EIF4EBP1 | Q13541 | PICK1 | Homo sapiens | Q9NRD5 | 32296183 | |
|
Intra
|
EIF4EBP1 | Q13541 | PICK1 | Homo sapiens | Q9NRD5 | 32296183 | |
|
Intra
|
EIF4EBP1 | Q13541 | PICK1 | Homo sapiens | Q9NRD5 | 32296183 |
Recombinant EIF4EBP1 Proteins
| Cat. No. | Nom du produit | Accession | Pureté |
|---|---|---|---|
| HY-P70415 | EIF4EBP1 Protein, Human (His) | Q13541 (M1-I118) | ≥ 90%, as determined by reducing SDS-PAGE. |
EIF4EBP1 Anticorps
| Cat. No. | Nom du produit | Application | Reactivity |
|---|---|---|---|
| HY-P80526 | eIF4EBP1 Antibody (YA650) | WB, IHC-P, IP | Human, Mouse, Rat, Hamster |
| HY-P80526A | eIF4EBP1 Antibody (YA650)(PBS only) | WB, IHC-P, IP | Human, Mouse, Rat, Hamster |
| HY-P80786 | Phospho-eIF4EBP1 (Thr46) Antibody (YA230) | WB, IHC-P, IP | Human, Mouse, Rat |
| HY-P80786A | Phospho-eIF4EBP1 (Thr46) Antibody (YA230)(PBS only) | WB, IHC-P, IP | Human, Mouse, Rat |
| HY-P84548 | Phospho-eIF4EBP1 (Ser65) Antibody (YA4245) | IHC-P, ICC/IF, FC, ELISA | Human |
| HY-P84548A | Phospho-eIF4EBP1 (Ser65) Antibody (YA4245)(PBS only) | IHC-P, ICC/IF, FC, ELISA | Human |
| HY-P86088 | Phospho-eIF4EBP1(Thr37/46) Antibody (YA5780) | WB, ICC/IF, ELISA | Human, Mouse, Rat |
| HY-P86332 | eIF4EBP1 Antibody (YA6024) | WB, IHC-P, ICC/IF, IP, ELISA | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Tuberous Sclerosis |
|
|
| Rhabdomyosarcoma |
|
|
| Muscle Hypertrophy |
|
|
| Squamous Cell Carcinoma |
|
|
| Subependymal Glioma |
|
|
| Kidney Angiomyolipoma |
|
|
| Benign Ependymoma |
|
|
| Subependymal Giant Cell Astrocytoma |
|
|
| Autism |
|
|
| Pyriform Sinus Cancer |
|
|
| Gastric Cancer |
|
|
| Cowden Syndrome 1 |
|
|
| Colorectal Cancer |
|
|
| Endometrial Cancer |
|
|
| Renal Cell Carcinoma, Nonpapillary |
|
|
| Pancreatic Cancer |
|
|
| Leukemia, Chronic Myeloid |
|
|
| Prostate Cancer |
|
|
| Liver Carcinoma In Situ |
|
|
| Ovarian Cancer |
|
|
| Autism Spectrum Disorder |
|
|
| Combined Oxidative Phosphorylation Deficiency 33 |
|
|
| Breast Cancer |
|
|
| Cowden Syndrome |
|
|
| Mantle Cell Lymphoma |
|
|
| Parkinson Disease, Late-Onset |
|
|
| Leukemia, Acute Myeloid |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Felis catus | EIF4EBP1 | VGNC | VGNC:61793 |
| Mus musculus | EIF4EBP1 | MGD | MGI:103267 |
| Rattus norvegicus | EIF4EBP1 | RGD | RGD:620259 |
| Canis familiaris | EIF4EBP1 | VGNC | VGNC:40286 |
| Macaca mulatta | EIF4EBP1 | VGNC | VGNC:104450 |
| Bos taurus | EIF4EBP1 | VGNC | VGNC:28412 |
| Others | EIF4EBP1 | NCBI |