Mtor - mechanistic target of rapamycin kinase Gene
Also Known as FRAP; flat; FRAP2; Frap1; RAFT1; RAPT1; 2610315D21Rik
Species: Mus musculus
About Mtor
This gene has 4 transcripts (splice variants), 217 orthologues, 5 paralogues and is associated with 64 phenotypes. Ubiquitous expression in testis adult (RPKM 23.), kidney adult (RPKM 12.8) and 28 other tissues.
Summary
Enables protein serine/threonine kinase activity and ribosome binding activity. Involved in several processes, including 'de novo' pyrimidine nucleobase biosynthetic process; T-helper 1 cell lineage commitment; and neuronal action potential. Acts upstream of or within several processes, including heart development; positive regulation of cellular component biogenesis; and regulation of protein phosphorylation. Located in cytosol; dendrite; and nucleus. Part of TORC1 complex. Colocalizes with PML body. Is expressed in central nervous system; early conceptus; oocyte; respiratory system; and retina. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; kidney angiomyolipoma; lung disease (multiple); prostate cancer; and type 2 diabetes mellitus. Orthologous to human mTOR (mechanistic target of rapamycin kinase). [provided by Alliance of Genome Resources, Apr 2022]
Mtor Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_020009.2 | NP_064393.2 | serine/threonine-protein kinase mTOR |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
12150926 | MGI |
| enables protein serine/threonine kinase activity |
IDA
IDA: Inferred from direct assay
|
11707573 | MGI |
| enables ribosome binding |
IDA
IDA: Inferred from direct assay
|
21045808 | MGI |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| colocalizes with PML body |
IDA
IDA: Inferred from direct assay
|
16915281 | MGI |
| part of TORC1 complex |
IDA
IDA: Inferred from direct assay
|
12718876 | MGI |
| located in cytosol |
IDA
IDA: Inferred from direct assay
|
16915281 | MGI |
| located in dendrite |
IDA
IDA: Inferred from direct assay
|
23836929 | MGI |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
18347059 | MGI |
Mtor Protein Structure
TEL1: COG5032 (362 - 2548)
HEAT: sd00044 (654 - 680)
HEAT: sd00044 (690 - 720)
HEAT: sd00044 (728 - 758)
HEAT: sd00044 (771 - 804)
HEAT: sd00044 (816 - 846)
HEAT: sd00044 (954 - 980)
HEAT: sd00044 (992 - 1020)
HEAT: sd00044 (1032 - 1061)
HEAT: sd00044 (1072 - 1098)
HEAT: sd00044 (1110 - 1141)
HEAT: sd00044 (1153 - 1179)
- 0
- 400
- 800
- 1200
- 1600
- 2000
- 2400
- 2549 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
serine/threonine-protein kinase mTOR |
|
|
Mtor Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Cross
|
Mtor | Q9JLN9 | RPTOR | Homo sapiens | Q8N122 | 24036451 | |
|
Intra
|
Mtor | Q9JLN9 | Eif3f | Mus musculus | Q9DCH4 | 16541103 | |
|
Intra
|
Mtor | Q9JLN9 | Rictor | Mus musculus | Q6QI06 | 20801936 | |
|
Intra
|
Mtor | Q9JLN9 | Rictor | Mus musculus | Q6QI06 | 18566586 | |
|
Intra
|
Mtor | Q9JLN9 | Rictor | Mus musculus | Q6QI06 | 21045808 | |
|
Intra
|
Mtor | Q9JLN9 | Rictor | Mus musculus | Q6QI06 | 21045808 | |
|
Intra
|
Mtor | Q9JLN9 | Rictor | Mus musculus | Q6QI06 | 18664580 | |
|
Intra
|
Mtor | Q9JLN9 | Rptor | Mus musculus | Q8K4Q0 | 21045808 | |
|
Intra
|
Mtor | Q9JLN9 | Rptor | Mus musculus | Q8K4Q0 | 20801936 | |
|
Intra
|
Mtor | Q9JLN9 | Rptor | Mus musculus | Q8K4Q0 | 23966835 | |
|
Intra
|
Mtor | Q9JLN9 | Rptor | Mus musculus | Q8K4Q0 | 21045808 | |
|
Intra
|
Mtor | Q9JLN9 | Rptor | Mus musculus | Q8K4Q0 | 18664580 | |
|
Intra
|
Mtor | Q9JLN9 | Rptor | Mus musculus | Q8K4Q0 | 20801936 |