PI3K/mTOR-IN-18
PI3K/mTOR-IN-18 (Compound 12) is a highly selective dual PI3K/mTOR inhibitor. PI3K/mTOR-IN-18 shows antitumor effects via competitive binding to PI3Kα (Ki=0.130 nM) and mTOR (Ki=0.111 nM). PI3K/mTOR-IN-18 blocks the PI3K/AKT/mTOR pathway and inhibits tumor cell proliferation (IC50=144 nM). PI3K/mTOR-IN-18 is promising for research of solid tumors (e.g., breast, NSCLC).
For research use only. We do not sell to patients.
- CAS No.: 1220699-39-7
- Formula: C22H23N5O3
- Molecular Weight:405.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BT-20 | IC50 |
9.52 nM
Compound: 12
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Inhibition of PI3K in human BT20 cells assessed as inhibition of AKT Ser473 phosphorylation
Inhibition of PI3K in human BT20 cells assessed as inhibition of AKT Ser473 phosphorylation
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[PMID: 24900568] |
Chemical Information
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CAS No. 1220699-39-7
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Molecular Weight 405.45
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Formula C22H23N5O3
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SMILES
O=C1N([C@H]2CC[C@@H](CC2)O)C3=C(N1C)C=NC4=CC=C(C5=CN=C(OC)C=C5)N=C34
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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