Dehydrovomifoliol
Based on 1 Customer Validation
Dehydrovomifoliol is a AKT/mTOR dual inhibitor. Dehydrovomifoliol reduces lipid accumulation and lipogenesis by inhibiting the AKT/mTOR signaling pathway. Dehydrovomifoliol is used in nonalcoholic fatty liver disease research (NAFLD) .
For research use only. We do not sell to patients.
- Purity : 98.88%
- CAS No.: 39763-33-2
- Formula: C13H18O3
- Molecular Weight:222.28
-
Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>64.4 μM
Compound: 12
|
Cytostatic activity against human A549 cells after 48 cells by MTT assay
Cytostatic activity against human A549 cells after 48 cells by MTT assay
|
[PMID: 21561060] |
| C8166 | CC50 |
>450.5 μM
Compound: 12
|
Cytotoxicity against human C8166 cells after 3 days by MTT assay
Cytotoxicity against human C8166 cells after 3 days by MTT assay
|
[PMID: 21561060] |
| C8166 | EC50 |
>450.5 μM
Compound: 12
|
Antiviral activity against Human immunodeficiency virus 1 3B infected in human C8166 cells assessed as numbers of syncytia after 3 days by MTT assay
Antiviral activity against Human immunodeficiency virus 1 3B infected in human C8166 cells assessed as numbers of syncytia after 3 days by MTT assay
|
[PMID: 21561060] |
| HL-60 | IC50 |
>64.4 μM
Compound: 12
|
Cytostatic activity against human HL60 cells after 48 cells by MTT assay
Cytostatic activity against human HL60 cells after 48 cells by MTT assay
|
[PMID: 21561060] |
| HT-29 | IC50 |
>10 μM
Compound: S7
|
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay
|
[PMID: 30057155] |
| HT-29 | IC50 |
>10 μM
Compound: S7
|
Inhibition of mitochondrial membrane potential in human HT-29 cells after 3 hrs by JC-1 staining based fluorescence assay
Inhibition of mitochondrial membrane potential in human HT-29 cells after 3 hrs by JC-1 staining based fluorescence assay
|
[PMID: 30057155] |
| MCF7 | IC50 |
>64.4 μM
Compound: 12
|
Cytostatic activity against human MCF7 cells after 48 cells by MTT assay
Cytostatic activity against human MCF7 cells after 48 cells by MTT assay
|
[PMID: 21561060] |
| MDA-MB-435 | IC50 |
>10 μM
Compound: S7
|
Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay
Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay
|
[PMID: 30057155] |
| OVCAR-3 | IC50 |
>10 μM
Compound: S7
|
Cytotoxicity against human OVCAR3 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay
Cytotoxicity against human OVCAR3 cells assessed as reduction in cell viability after 72 hrs by CellTiter 96 aqueous one solution assay
|
[PMID: 30057155] |
| RAW264.7 | IC50 |
>50 μM
Compound: 10
|
Inhibition of LPS-induced IL-1beta production in mouse RAW264.7 cells after 24 hrs by ELISA
Inhibition of LPS-induced IL-1beta production in mouse RAW264.7 cells after 24 hrs by ELISA
|
[PMID: 24963714] |
| RAW264.7 | IC50 |
>64.4 μM
Compound: 12
|
Antiinflammatory against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production
Antiinflammatory against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production
|
[PMID: 21561060] |
| RAW264.7 | IC50 |
38.5 μM
Compound: 10
|
Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess reagent based assay
Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess reagent based assay
|
[PMID: 24963714] |
| SMMC-7721 | IC50 |
>64.4 μM
Compound: 12
|
Cytostatic activity against human SMMC7721 cells after 48 cells by MTT assay
Cytostatic activity against human SMMC7721 cells after 48 cells by MTT assay
|
[PMID: 21561060] |
| SW480 | IC50 |
>64.4 μM
Compound: 12
|
Cytostatic activity against human SW480 cells after 48 cells by MTT assay
Cytostatic activity against human SW480 cells after 48 cells by MTT assay
|
[PMID: 21561060] |
Chemical Information
-
CAS No. 39763-33-2
-
Appearance Oil
-
Molecular Weight 222.28
-
Formula C13H18O3
-
Color Colorless to light yellow
-
SMILES
CC(/C=C/[C@](C(C)(C1)C)(C(C)=CC1=O)O)=O
-
Structure Classification
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Protocols
-
3T3-L1 preadipocyte-to-adipocyte differentiation
3T3-L1 preadipocytes are induced to differentiate after growth arrest using adipogenic media containing insulin, dexamethasone, and IBMX; differentiation is assessed by lipid-droplet accumulation, triglyceride increase, Oil Red O staining, and adipocyte-marker induction such as PPARγ and C/EBPα.
-
Research Protocol for Metabolic Diseases
AMP-activated protein kinase, AMPK, is a conserved cellular energy sensor that responds to reduced cellular energy status and coordinates metabolism by increasing ATP-generating catabolic pathways while suppressing ATP-consuming anabolic processes. In metabolic disease research, the AMPK pathway is experimentally relevant because it regulates hepatic lipid synthesis, fatty acid oxidation, glucose production, skeletal-muscle glucose disposal, mTORC1-linked biosynthesis, autophagy, mitochondrial homeostasis, and whole-body energy balance. The central pathway logic is that energy stress, metformin, exercise-like stimulation, or direct AMPK activators increase AMPKα Thr172 phosphorylation and downstream substrate phosphorylation, including ACC and RAPTOR. Phosphorylation of ACC suppresses lipogenesis and supports fatty acid oxidation, whereas phosphorylation of RAPTOR suppresses mTORC1 signaling and links cellular energy status to growth and protein synthesis control. The pathway is linked
-
Lipid Droplets: Oil Red O/Sudan Dye Lipid Staining
Lipid droplets are intracellular organelles with a neutral-lipid core that stores triacylglycerols and sterol esters, and Oil Red O or Sudan dyes detect these hydrophobic lipid deposits by partitioning into retained lipids in fresh or frozen specimens. Oil Red O stains neutral triglycerides and lipids in frozen tissue sections or air-dried cytologic preparations, while Sudan Black B has also been used as a histochemical fat stain for lipid-rich tissue structures.
Purity & Documentation
-
Data Sheet (267 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dehydrovomifoliol Related Classifications
HY-137996 Related Classifications
Powered by Bioz