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Cat. No.: HY-10681S1

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Gedatolisib-d₆

(Synonyms: PKI-587-d₆; PF-05212384-d₆)

Gedatolisib-d₆ (PKI-587-d₆) is the deuterium labeled Gedatolisib (HY-10681). Gedatolisib (PKI-587) is a highly potent dual inhibitor of PI3Kα, PI3Kγ, and mTOR with IC₅₀s of 0.4 nM, 5.4 nM and 1.6 nM, respectively. Gedatolisib is equally effective in both complexes of mTOR, mTORC1 and mTORC2.

For research use only. We do not sell to patients.

Formula: C₃₂H₃₅D₆N₉O₄
Molecular Weight:621.76

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Gedatolisib-d₆ Chemical Structure

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Biological Activity
- Description
- In Vitro
- Application
Chemical Information
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Biological Activity

Description

Gedatolisib-d₆ (PKI-587-d₆) is the deuterium labeled Gedatolisib (HY-10681). Gedatolisib (PKI-587) is a highly potent dual inhibitor of PI3Kα, PI3Kγ, and mTOR with IC₅₀s of 0.4 nM, 5.4 nM and 1.6 nM, respectively^[1]. Gedatolisib is equally effective in both complexes of mTOR, mTORC1 and mTORC2^[2].

All mTOR Isoforms :

All PI3K Isoforms :

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

Unlabeled Cas 1197160-78-3
Molecular Weight 621.76
Formula C₃₂H₃₅D₆N₉O₄
SMILES

O=C(NC1=CC=C(C2=NC(N3CCOCC3)=NC(N4CCOCC4)=N2)C=C1)NC5=CC=C(C=C5)C(N6CCC(CC6)N(C([2H])([2H])[2H])C([2H])([2H])[2H])=O
Synonyms

PKI-587-d₆; PF-05212384-d₆
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.