country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-187134

Copy Link Print Information

mTOR-IN-31

mTOR-IN-31 is a selective mTOR inhibitor with an IC₅₀ of 0.9 nM. mTOR-IN-31 inhibits the proliferation of prostate cancer cells. mTOR-IN-31 is applicable for cancer-related research.

For research use only. We do not sell to patients.

CAS No.: 1144075-32-0
Formula: C₂₀H₂₁N₅O₂S
Molecular Weight:395.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

mTOR-IN-31 Chemical Structure

CAS No.: 1144075-32-0

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

mTOR-IN-31 is a selective mTOR inhibitor with an IC₅₀ of 0.9 nM. mTOR-IN-31 inhibits the proliferation of prostate cancer cells. mTOR-IN-31 is applicable for cancer-related research^[1].

IC₅₀ & Target^[1]

mTOR

0.9 nM (IC₅₀)

PI3Kα

423 nM (IC₅₀)

All mTOR Isoforms :

All PI3K Isoforms :

In Vitro

mTOR-IN-31 (compound 9a) potently inhibits recombinant mTOR with an IC₅₀ of 0.9 nM, and exhibits over 1000-fold selectivity against recombinant PI3K-α^[1].
mTOR-IN-31 inhibits the proliferation of human prostate cancer cell line LNCaP (IC₅₀ = 85 nM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1144075-32-0
Molecular Weight 395.48
Formula C₂₀H₂₁N₅O₂S
SMILES

O=C(NC)NC1=CC=C(C2=NC3=C(C(N4CC5OC(CC5)C4)=N2)SC=C3)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Verheijen J C, et al. Discovery of 2-arylthieno[3,2-d]pyrimidines containing 8-oxa-3-azabicyclo[3.2.1]octane in the 4-position as potent inhibitors of mTOR with selectivity over PI3K. Bioorg Med Chem Lett, 2010, 20(1): 375-379.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote

Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

mTOR-IN-31

All mTOR Isoforms

All PI3K Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

mTOR-IN-31 Related Classifications

HY-187134 Related Classifications