2. Cytoskeleton Protein Tyrosine Kinase/RTK JAK/STAT Signaling Cell Cycle/DNA Damage PI3K/Akt/mTOR
  3. Cadherin EGFR PERK Akt mTOR
  4. Anti-Mouse E-Cadherin/CD324 Antibody (DECMA-1)

Anti-Mouse E-Cadherin/CD324 Antibody (DECMA-1) 

Cat. No.: HY-P990248
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Anti-Mouse E-Cadherin/CD324 Antibody (DECMA-1) is an anti-mouse E-Cadherin/CD324 IgG1 monoclonal antibody. Anti-Mouse E-Cadherin/CD324 Antibody (DECMA-1) can downregulate the HER signaling axis and PI3K/Akt/mTOR signaling pathway. Anti-Mouse E-Cadherin/CD324 Antibody (DECMA-1) can inhibit the proliferation of tumor cells and induce their apoptosis. Anti-Mouse E-Cadherin/CD324 Antibody (DECMA-1) can be used for researches on cancer and inflammation conditions such as breast cancer, chronic compression injury (CCI) and asthma.

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Anti-Mouse E-Cadherin/CD324 Antibody (DECMA-1)

Anti-Mouse E-Cadherin/CD324 Antibody (DECMA-1) Estructura química

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Anti-Mouse E-Cadherin/CD324 Antibody (DECMA-1) Related Antibodies

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Descripciòn

Anti-Mouse E-Cadherin/CD324 Antibody (DECMA-1) is an anti-mouse E-Cadherin/CD324 IgG1 monoclonal antibody. Anti-Mouse E-Cadherin/CD324 Antibody (DECMA-1) can downregulate the HER signaling axis and PI3K/Akt/mTOR signaling pathway. Anti-Mouse E-Cadherin/CD324 Antibody (DECMA-1) can inhibit the proliferation of tumor cells and induce their apoptosis. Anti-Mouse E-Cadherin/CD324 Antibody (DECMA-1) can be used for researches on cancer and inflammation conditions such as breast cancer, chronic compression injury (CCI) and asthma[1][2][3].

Isotype

Rat IgG1 kappa
Recommend Isotype Controls
Species Reactivity

Mouse
IC50 & Target[1]

Akt

 

mTOR

 

HER1

 

HER2

 

HER3

 

HER4

 

In Vitro

Anti-Mouse E-Cadherin/CD324 Antibody (DECMA-1) (20 or 400 µg/mL, 48 h) significantly inhibits cell proliferation and induces apoptosis in MCF-7 and BT474 drug (Trastuzumab) (HY-P9907)-resistant cell line[1].
Anti-Mouse E-Cadherin/CD324 Antibody (DECMA-1) downregulates the HER (HER1, HER2, HER3 and HER4) signaling axis and PI3K/Akt/mTOR signaling pathway (pERK1/2, pAkt, pmTOR, pRaptor and p4E-BP1) in MCF-7 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse E-Cadherin/CD324 Antibody (DECMA-1) Related Antibodies

Cell Viability Assay[1]

Cell Line: MCF-7 and BT474-TtzmR cells
Concentration: 20 or 400 µg/mL
Incubation Time: 48 h
Result: Significantly reduced the number of surviving cells.

ELISA Assay[1]

Cell Line: MCF-7 and BT474-TtzmR cells
Concentration: 20 or 400 µg/mL
Incubation Time: 48 h
Result: Significantly increased the number of apoptotic cells.
In Vivo

Anti-Mouse E-Cadherin/CD324 Antibody (DECMA-1) (1 mg/kg, i.p., once a week, from 47 to 90 days of age) significantly delays the occurrence of tumors in female MMTV-PyMT mice with a spontaneous breast cancer model[1].
Anti-Mouse E-Cadherin/CD324 Antibody (DECMA-1) (1 μg, intrathecal injection, once daily, for 14 days) can reverse the analgesic effect of glial cell-derived neurotrophic factor (GDNF) in male C57BL/6 mice with a chronic compression injury (CCI) model[2].
Anti-Mouse E-Cadherin/CD324 Antibody (DECMA-1) (10 mg/kg, i.p., single dose, 30 min after the second stimulation or 30 min after the first OVA challenge) significantly reduces inflammatory response in male BALB/c mice with a toluene diisocyanate (TDI) or OVA (HY-W250978)/CFA (HY-153808) induced asthma model[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female MMTV-PyMT mice with a spontaneous breast cancer model[1]
Dosage: 1 mg/kg
Administration: Intraperitoneal injection (i.p.), once a week, from 47 to 90 days of age
Result: Significantly reduced the number and volume of tumors.
Inhibited the proliferation of tumor cells and induced apoptosis.
Downregulated HER1-4 receptors and their downstream signaling molecules (such as pAkt, pmTOR, survivor).
Was non-toxic to normal tissues.
Animal Model: Male C57BL/6 mice (20-25 g) with a chronic compression injury (CCI) model caused by surgery[2]
Dosage: 1 μg
Administration: Intrathecal injection, once daily, for 14 days
Result: Significantly inhibited the analgesic effect of GDNF.
Blocked the regulation of the E-cadherin/p120ctn signaling pathway by GDNF.
Animal Model: Toluene diisocyanate (TDI) or OVA/CFA induced male BALB/c mice (6-8 weeks, 20 g)[3]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection (i.p.), single dose, 30 min after the second stimulation or 30 min after the first OVA challenge
Result: Significantly reduced sE cadherin levels in bronchoalveolar lavage fluid (BALF).
Reduced inflammatory cell infiltration, airway hyperresponsiveness (AHR), and smooth muscle thickening.
Had no effect on goblet cell metaplasia.
Gene ID

12550  [NCBI]

Accession
Application

in vivo E-Cadherin neutralization; In vitro E-Cadherin neutralization; Immunofluorescence; Immuno
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Peso molecular

150 kDa

SMILES

[Anti-Mouse E-Cadherin/CD324 Antibody (DECMA-1)]
Formulation

Please refer to the lot-specific COA for specific buffer information.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
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Anti-Mouse E-Cadherin/CD324 Antibody (DECMA-1) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse E-Cadherin/CD324 Antibody (DECMA-1)CadherinEGFRPERKAktmTOREpidermal growth factor receptorErbB-1HER1Protein kinase R-like endoplasmic reticulum kinasePKR-like endoplasmic reticulum kinasePKBProtein kinase BMammalian target of RapamycinE-Cadherin/CD324HERERK1/2CCIbreast cancerMCF-7BT474Inhibitorinhibitorinhibit

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Nombre del producto:
Anti-Mouse E-Cadherin/CD324 Antibody (DECMA-1)
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HY-P990248
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