Cdh1 - cadherin 1 Gene

Also Known as Um; UVO; Ecad; ARC-1; E-cad; L-CAM

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12550

Summary

This gene encodes E-cadherin, a calcium-dependent cell adhesion molecule that functions in the establishment and maintenance of epithelial cell morphology during embryongenesis and adulthood. The encoded preproprotein undergoes proteolytic processing to generate a mature protein. Targeted mutations disrupting binding of calcium to the encoded protein in mice cause death in utero due to failed blastocyst and trophectoderm formation. This gene is located adjacent to a related Cadherin gene on chromosome 8. [provided by RefSeq, Oct 2015]

Cdh1 Products (1)

mRNA Protein Name
NM_009864.3 NP_033994.1 cadherin-1 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables alpha-catenin binding IPI
IPI: Inferred from physical interaction
8853988 MGI
enables beta-catenin binding IDA
IDA: Inferred from direct assay
7806582 MGI
enables beta-catenin binding IPI
IPI: Inferred from physical interaction
8853988 MGI
enables calcium ion binding IDA
IDA: Inferred from direct assay
12460580 MGI
enables cytoskeletal protein binding IMP
IMP: Inferred from mutant phenotype
2519616 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
12460580 MGI
enables molecular adaptor activity EXP
EXP: Inferred from Experiment
11121423 MGI
enables molecular adaptor activity IDA
IDA: Inferred from direct assay
11121423 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9531566 MGI
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
18794329 MGI
enables protein phosphatase binding IPI
IPI: Inferred from physical interaction
16973135 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
17507657 MGI
acts upstream of or within bicellular tight junction assembly IMP
IMP: Inferred from mutant phenotype
15775979 MGI
acts upstream of or within calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IDA
IDA: Inferred from direct assay
15023525 MGI
acts upstream of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
22766025 MGI
acts upstream of or within cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
15148305 MGI
acts upstream of or within cell-cell adhesion mediated by cadherin IMP
IMP: Inferred from mutant phenotype
17507657 MGI
acts upstream of or within cellular response to amino acid stimulus IDA
IDA: Inferred from direct assay
20548288 MGI
involved in cochlea development IDA
IDA: Inferred from direct assay
30639848 MGI
acts upstream of or within cochlea development IMP
IMP: Inferred from mutant phenotype
21925491 MGI
involved in decidualization IMP
IMP: Inferred from mutant phenotype
22378759 MGI
involved in embryo implantation IMP
IMP: Inferred from mutant phenotype
22378759 MGI
acts upstream of or within epithelial cell morphogenesis IMP
IMP: Inferred from mutant phenotype
22766025 MGI
acts upstream of or within establishment of skin barrier IMP
IMP: Inferred from mutant phenotype
15775979 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
15775979 MGI
acts upstream of or within intestinal epithelial cell development IMP
IMP: Inferred from mutant phenotype
22766025 MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
22766025 MGI
acts upstream of or within negative regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
22766025 MGI
acts upstream of or within negative regulation of protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
17507657 MGI
acts upstream of or within negative regulation of protein processing IMP
IMP: Inferred from mutant phenotype
17344476 MGI
acts upstream of or within positive regulation of cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
2519616 MGI
involved in protein localization to plasma membrane IDA
IDA: Inferred from direct assay
7806582 MGI
acts upstream of or within regulation of branching involved in salivary gland morphogenesis IMP
IMP: Inferred from mutant phenotype
18816447 MGI
acts upstream of or within regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: Inferred from direct assay
15192701 MGI
acts upstream of or within regulation of neuron migration IDA
IDA: Inferred from direct assay
23434913 MGI
acts upstream of or within regulation of protein localization IMP
IMP: Inferred from mutant phenotype
15775979 MGI
acts upstream of or within regulation of protein localization to cell surface IMP
IMP: Inferred from mutant phenotype
15775979 MGI
acts upstream of or within salivary gland cavitation IMP
IMP: Inferred from mutant phenotype
18816447 MGI
acts upstream of or within sensory perception of sound IMP
IMP: Inferred from mutant phenotype
21925491 MGI
acts upstream of or within trophectodermal cell differentiation IMP
IMP: Inferred from mutant phenotype
17138661 MGI
involved in uterine epithelium development IMP
IMP: Inferred from mutant phenotype
22378759 MGI
Cellular Component GO Annotation Evidence References Source
located in Schmidt-Lanterman incisure IDA
IDA: Inferred from direct assay
20237282 MGI
located in adherens junction IDA
IDA: Inferred from direct assay
8582267 MGI
located in apical junction complex IDA
IDA: Inferred from direct assay
17130295 MGI
located in apical part of cell IDA
IDA: Inferred from direct assay
14758363 MGI
located in axon IDA
IDA: Inferred from direct assay
17392463 MGI
located in axon terminus IDA
IDA: Inferred from direct assay
17392463 MGI
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
15788452 MGI
part of catenin complex IDA
IDA: Inferred from direct assay
8853988 MGI
part of catenin complex IMP
IMP: Inferred from mutant phenotype
11121423 MGI
located in cell periphery IDA
IDA: Inferred from direct assay
19289495 MGI
located in cell surface IDA
IDA: Inferred from direct assay
11511678 MGI
located in cell-cell junction IDA
IDA: Inferred from direct assay
9864371 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
23637336 MGI
part of flotillin complex IDA
IDA: Inferred from direct assay
24046456 MGI
located in lateral loop IDA
IDA: Inferred from direct assay
20237282 MGI
located in microvillus IDA
IDA: Inferred from direct assay
33129760 MGI
located in node of Ranvier IDA
IDA: Inferred from direct assay
20237282 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
8853988 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cadherin-1

  • E-cadherin

  • epithelial cadherin

  • uvomorulin

Recombinant Cdh1 Proteins

Cat. No. Product Name Accession Purity
HY-P700008 Cadherin-1/CD324 Protein, Mouse (HEK293, His) P09803 (D157-V709) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N16719 Picrasidine J Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdh1 NCBI NCBI:999