1. PI3K/Akt/mTOR
    Anti-infection
    Apoptosis
  2. PI3K
    Akt
    mTOR
    Parasite
    Apoptosis
  3. Hederacolchiside A1

Hederacolchiside A1 

Cat. No.: HY-N6950
Handling Instructions

Hederacolchiside A1, isolated from Pulsatilla chinensis, suppresses proliferation of tumor cells by inducing apoptosis through modulating PI3K/Akt/mTOR signaling pathway. Hederacolchiside A1 has antischistosomal activity, affecting parasite viability both in vivo and in vitro.

For research use only. We do not sell to patients.

Hederacolchiside A1 Chemical Structure

Hederacolchiside A1 Chemical Structure

CAS No. : 106577-39-3

Size Price Stock
1 mg USD 67 Ask For Quote & Lead Time
5 mg USD 202 Ask For Quote & Lead Time
10 mg USD 343 Ask For Quote & Lead Time

* Please select Quantity before adding items.

Top Publications Citing Use of Products

View All PI3K Isoform Specific Products:

View All Akt Isoform Specific Products:

View All mTOR Isoform Specific Products:

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Hederacolchiside A1, isolated from Pulsatilla chinensis, suppresses proliferation of tumor cells by inducing apoptosis through modulating PI3K/Akt/mTOR signaling pathway[1]. Hederacolchiside A1 has antischistosomal activity, affecting parasite viability both in vivo and in vitro[2].

IC50 & Target[1]

PI3K

 

Akt

 

mTOR

 

In Vitro

Hederacolchiside A1 reduces the mitochondrial membrane potential and Bcl-2 protein levels, whereas cleaved caspase-3 was higher[1].
Hederacolchiside A1 effectively inhibits the phosphorylations of phosphatidylinositol 3 kinase (PI3K), protein kinase B (Akt), and mammalian target of rapamycin (mTOR) [1].

In Vivo

hederacolchiside A1 (3.0, 4.5, and 6.0 mg/kg, ip) can significantly inhibit the weight of tumor in an H22 xenograft model[1].
Hederacolchiside A1 (3.25, 7.5, and 15.0 mg/kg, ig) can significantly inhibit the weight of tumor in nude mice xenograft tumor models using human breast carcinoma MCF-7 cells[1].

Molecular Weight

897.10

Formula

C₄₇H₇₆O₁₆

CAS No.

106577-39-3

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Hederacolchiside A1Hederacolchiside A 1Hederacolchiside A-1PI3KAktmTORParasiteApoptosisPhosphoinositide 3-kinasePKBProtein kinase BMammalian target of RapamycinInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product name:
Hederacolchiside A1
Cat. No.:
HY-N6950
Quantity:
MCE Japan Authorized Agent: