1. PI3K/Akt/mTOR
    Anti-infection
    Apoptosis
  2. PI3K
    Akt
    mTOR
    Parasite
    Apoptosis
  3. Hederacolchiside A1

Hederacolchiside A1 

Cat. No.: HY-N6950 Purity: >99.0%
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Hederacolchiside A1, isolated from Pulsatilla chinensis, suppresses proliferation of tumor cells by inducing apoptosis through modulating PI3K/Akt/mTOR signaling pathway. Hederacolchiside A1 has antischistosomal activity, affecting parasite viability both in vivo and in vitro.

For research use only. We do not sell to patients.

Hederacolchiside A1 Chemical Structure

Hederacolchiside A1 Chemical Structure

CAS No. : 106577-39-3

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5 mg USD 202 In-stock
Estimated Time of Arrival: December 31
10 mg USD 343 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Hederacolchiside A1, isolated from Pulsatilla chinensis, suppresses proliferation of tumor cells by inducing apoptosis through modulating PI3K/Akt/mTOR signaling pathway[1]. Hederacolchiside A1 has antischistosomal activity, affecting parasite viability both in vivo and in vitro[2].

IC50 & Target[1]

PI3K

 

Akt

 

mTOR

 

In Vitro

Hederacolchiside A1 reduces the mitochondrial membrane potential and Bcl-2 protein levels, whereas cleaved caspase-3 was higher[1].
Hederacolchiside A1 effectively inhibits the phosphorylations of phosphatidylinositol 3 kinase (PI3K), protein kinase B (Akt), and mammalian target of rapamycin (mTOR) [1].

In Vivo

hederacolchiside A1 (3.0, 4.5, and 6.0 mg/kg, ip) can significantly inhibit the weight of tumor in an H22 xenograft model[1].
Hederacolchiside A1 (3.25, 7.5, and 15.0 mg/kg, ig) can significantly inhibit the weight of tumor in nude mice xenograft tumor models using human breast carcinoma MCF-7 cells[1].

Molecular Weight

897.10

Formula

C₄₇H₇₆O₁₆

CAS No.

106577-39-3

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

References

Purity: >99.0%

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Keywords:

Hederacolchiside A1Hederacolchiside A 1Hederacolchiside A-1PI3KAktmTORParasiteApoptosisPhosphoinositide 3-kinasePKBProtein kinase BMammalian target of RapamycinInhibitorinhibitorinhibit

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Hederacolchiside A1
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