Cat. No.: HY-N8198

Ardisiacrispin B

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Ardisiacrispin B displays cytotoxic effects in multi-factorial agent resistant cancer cells via ferroptotic and apoptotic cell death.

For research use only. We do not sell to patients.

Purity: 99.94%
CAS No.: 112766-96-8
Formula: C₅₃H₈₆O₂₂
Molecular Weight:1075.24

Storage:

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Ardisiacrispin B Chemical Structure

CAS No.: 112766-96-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Ardisiacrispin B displays cytotoxic effects in multi-factorial agent resistant cancer cells via ferroptotic and apoptotic cell death^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	3.6 μM Compound: 10, ardisiacrispin B	Cytotoxicity against human A549 cell line by MTT assay Cytotoxicity against human A549 cell line by MTT assay	[PMID: 17243725]
Bel-7402	IC₅₀	4.46 mM Compound: 9	Cytotoxicity against human Bel7402 cells after 72 hrs by MTT assay Cytotoxicity against human Bel7402 cells after 72 hrs by MTT assay	[PMID: 22940450]
HepG2	IC₅₀	1.53 μM Compound: 12	Cytotoxic activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
HepG2	IC₅₀	20.96 mM Compound: 9	Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 22940450]
HL-60	IC₅₀	22.58 μM Compound: 12	Cytotoxic activity against human HL60 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human HL60 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
HL-60	IC₅₀	3.2 μM Compound: 10, ardisiacrispin B	Cytotoxicity against human HL60 cell line by MTT assay Cytotoxicity against human HL60 cell line by MTT assay	[PMID: 17243725]
KB	IC₅₀	1.6 μM Compound: 12	Cytotoxic activity against human KB cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human KB cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
L02	IC₅₀	>100 mM Compound: 9	Cytotoxicity against human HL-7702 cells after 72 hrs by MTT assay Cytotoxicity against human HL-7702 cells after 72 hrs by MTT assay	[PMID: 22940450]
LNCaP	IC₅₀	9.7 μM Compound: 12	Cytotoxic activity against human LNCAP cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human LNCAP cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
Lu1	IC₅₀	1.41 μM Compound: 12	Cytotoxic activity against human Lu1 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human Lu1 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
MDA-MB-231	IC₅₀	11.76 μM Compound: 12	Cytotoxic activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
MKN-7	IC₅₀	1.27 μM Compound: 12	Cytotoxic activity against human MKN7 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human MKN7 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
SW480	IC₅₀	1.24 μM Compound: 12	Cytotoxic activity against human SW480 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human SW480 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]

Chemical Information

CAS No. 112766-96-8
Appearance Solid
Molecular Weight 1075.24
Formula C₅₃H₈₆O₂₂
Color White to off-white
SMILES

C[C@]12[C@]3(CC[C@@]4([H])[C@]2(CC[C@]5([H])[C@@]4(CC[C@@H](C5(C)C)O[C@H]6[C@@H]([C@H]([C@H](CO6)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O)O)O[C@H]8[C@@H]([C@@H]([C@H]([C@@H](O8)C)O)O)O)O)O[C@@H]9O[C@@H]([C@H]([C@@H]([C@H]9O)O)O)CO)C)C)[C@@]%10([H])[C@@]([C@@H](C1)O)(CC[C@@](C)(C%10)C=O)CO3
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (93.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

0.9300 mL

4.6501 mL

9.3002 mL

5 mM

0.1860 mL

0.9300 mL

1.8600 mL

10 mM

0.0930 mL

0.4650 mL

0.9300 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Armelle T Mbaveng, et al. A naturally occuring triterpene saponin ardisiacrispin B displayed cytotoxic effects in multi-factorial drug resistant cancer cells via ferroptotic and apoptotic cell death. Phytomedicine. 2018 Apr 1;43:78-85. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	0.9300 mL	4.6501 mL	9.3002 mL	23.2506 mL
	5 mM	0.1860 mL	0.9300 mL	1.8600 mL	4.6501 mL
	10 mM	0.0930 mL	0.4650 mL	0.9300 mL	2.3251 mL
	15 mM	0.0620 mL	0.3100 mL	0.6200 mL	1.5500 mL
	20 mM	0.0465 mL	0.2325 mL	0.4650 mL	1.1625 mL
	25 mM	0.0372 mL	0.1860 mL	0.3720 mL	0.9300 mL
	30 mM	0.0310 mL	0.1550 mL	0.3100 mL	0.7750 mL
	40 mM	0.0233 mL	0.1163 mL	0.2325 mL	0.5813 mL
	50 mM	0.0186 mL	0.0930 mL	0.1860 mL	0.4650 mL
	60 mM	0.0155 mL	0.0775 mL	0.1550 mL	0.3875 mL
	80 mM	0.0116 mL	0.0581 mL	0.1163 mL	0.2906 mL

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Ardisiacrispin B

Apoptosis Compound Library

Immunology/Inflammation Compound Library

Natural Product Library

Glycoside Compound Library

Ferroptosis Compound Library

Terpenoids Library

Traditional Chinese Medicine Active Compound Library

Anti-inflammatory Traditional Chinese Medicine Active Compound Library

Plant-Sourced Natural Product Library

Heterocyclic Compound Library

Cell Death Library

Anti-Drug-Resistant Compound Library

Bioactive Compound Library Max

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Miao Ethnicity Medicine Compound Library

Heat-Clearing and Detoxification Traditional Chinese Medicine Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Mongolian Medicine Compound Library

Mass Spectrometry Natural Product Library

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Ardisiacrispin B

Apoptosis Compound Library

Immunology/Inflammation Compound Library

Natural Product Library

Glycoside Compound Library

Ferroptosis Compound Library

Terpenoids Library

Traditional Chinese Medicine Active Compound Library

Anti-inflammatory Traditional Chinese Medicine Active Compound Library

Plant-Sourced Natural Product Library

Heterocyclic Compound Library

Cell Death Library

Anti-Drug-Resistant Compound Library

Bioactive Compound Library Max

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Miao Ethnicity Medicine Compound Library

Heat-Clearing and Detoxification Traditional Chinese Medicine Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Mongolian Medicine Compound Library

Mass Spectrometry Natural Product Library

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Ardisiacrispin B Related Classifications

HY-N8198 Related Classifications