1. PI3K/Akt/mTOR
  2. mTOR
    PI3K
  3. WYE-687 dihydrochloride

WYE-687 dihydrochloride 

Cat. No.: HY-15271A Purity: >98.0%
Handling Instructions

WYE-687 dihydrochloride is an ATP-competitive mTOR inhibitor with an IC50 of 7 nM. WYE-687 dihydrochloride concurrently inhibits activation of mTORC1 and mTORC2. WYE-687 also inhibits PI3Kα and PI3Kγ with IC50s of 81 nM and 3.11 μM, respectively.

For research use only. We do not sell to patients.

WYE-687 dihydrochloride Chemical Structure

WYE-687 dihydrochloride Chemical Structure

CAS No. : 1702364-87-1

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Description

WYE-687 dihydrochloride is an ATP-competitive mTOR inhibitor with an IC50 of 7 nM[1]. WYE-687 dihydrochloride concurrently inhibits activation of mTORC1 and mTORC2[2]. WYE-687 also inhibits PI3Kα and PI3Kγ with IC50s of 81 nM and 3.11 μM, respectively[1].

IC50 & Target[1][2]

mTOR

7 nM (IC50)

mTORC1

 

mTORC2

 

PI3K alpha

81 nM (IC50)

PI3K gamma

3.11 μM (IC50)

CK1 gamma1

17.8 μM (IC50)

p38 alpha

28.9 μM (IC50)

Molecular Weight

601.53

Formula

C₂₈H₃₄Cl₂N₈O₃

CAS No.

1702364-87-1

SMILES

O=C(OC)NC1=CC=C(C2=NC(N3CCOCC3)=C4C(N(C5CCN(CC6=CC=CN=C6)CC5)N=C4)=N2)C=C1.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >98.0%

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Keywords:

WYE-687WYE687WYE 687mTORPI3KMammalian target of RapamycinPhosphoinositide 3-kinaseInhibitorinhibitorinhibit

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Product name:
WYE-687 dihydrochloride
Cat. No.:
HY-15271A
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