Cat. No.: HY-118717

mTOR inhibitor WYE-28

Customer Review

Based on 1 Customer Validation

mTOR inhibitor WYE-28 (compound 28) is a selective inhibitor of mTOR (IC₅₀ = 0.08 nM). mTOR inhibitor WYE-28 inhibits PI3Kα with an IC₅₀ value of 6 nM. mTOR inhibitor WYE-28 shows a metabolic time (T_1/2) in nude mouse microsomes of 13 min.

For research use only. We do not sell to patients.

Purity: 99.25%
CAS No.: 1062172-60-4
Formula: C₃₀H₃₄N₈O₅
Molecular Weight:586.64

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

mTOR inhibitor WYE-28 Chemical Structure

CAS No.: 1062172-60-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All mTOR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	0.08 nM Compound: 28	Inhibition of flag-tagged truncated human mTOR (1360-2549) expressed in HEK293 cells by DELFIA assay Inhibition of flag-tagged truncated human mTOR (1360-2549) expressed in HEK293 cells by DELFIA assay	[PMID: 19645448]
LNCaP	IC₅₀	<1 nM Compound: 28	Cytotoxicity against human LNCAP cells after 3 days by MTS assay Cytotoxicity against human LNCAP cells after 3 days by MTS assay	[PMID: 19645448]

Chemical Information

CAS No. 1062172-60-4
Appearance Solid
Molecular Weight 586.64
Formula C₃₀H₃₄N₈O₅
Color White to off-white
SMILES

O=C(N1CCC(N2N=CC3=C(N=C(N=C32)C4=CC=C(C=C4)NC(NC5=CC=C(C=C5)CO)=O)N6CCOCC6)CC1)OC
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 60 mg/mL (102.28 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.7046 mL

8.5231 mL

17.0462 mL

5 mM

0.3409 mL

1.7046 mL

3.4092 mL

10 mM

0.1705 mL

0.8523 mL

1.7046 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zask A, et al. ATP-competitive inhibitors of the mammalian target of rapamycin: design and synthesis of highly potent and selective pyrazolopyrimidines. J Med Chem. 2009 Aug 27;52(16):5013-6. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.7046 mL	8.5231 mL	17.0462 mL	42.6156 mL
	5 mM	0.3409 mL	1.7046 mL	3.4092 mL	8.5231 mL
	10 mM	0.1705 mL	0.8523 mL	1.7046 mL	4.2616 mL
	15 mM	0.1136 mL	0.5682 mL	1.1364 mL	2.8410 mL
	20 mM	0.0852 mL	0.4262 mL	0.8523 mL	2.1308 mL
	25 mM	0.0682 mL	0.3409 mL	0.6818 mL	1.7046 mL
	30 mM	0.0568 mL	0.2841 mL	0.5682 mL	1.4205 mL
	40 mM	0.0426 mL	0.2131 mL	0.4262 mL	1.0654 mL
	50 mM	0.0341 mL	0.1705 mL	0.3409 mL	0.8523 mL
	60 mM	0.0284 mL	0.1421 mL	0.2841 mL	0.7103 mL
	80 mM	0.0213 mL	0.1065 mL	0.2131 mL	0.5327 mL
	100 mM	0.0170 mL	0.0852 mL	0.1705 mL	0.4262 mL

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mTOR inhibitor WYE-28

Bioactive Compound Library Max

Bioactive Compound Library

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PI3K/Akt/mTOR Compound Library

Stem Cell Signaling Compound Library

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Anti-Prostate Cancer Compound Library

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Highly Selective Inhibitors Library

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Radioprotector Library

MCE Bioactive Compound Library

Anti-Gastric Cancer Compound Library

Anti-Fibrosis Compound Library

Anti-Brain Cancer Compound Library

High-Throughput Bioactive Compound Library

Lactylation Compound Library

All mTOR Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

mTOR inhibitor WYE-28 Related Classifications

HY-118717 Related Classifications