Multi-target kinase-IN-15
Multi-target kinase-IN-15 is a multi-target kinase inhibitor that simultaneously inhibits kinases such as the PI3K family, mTOR, DNA-PK, and Src. Multi-target kinase-IN-15 competitively binds to the ATP pockets of multiple kinases, simultaneously blocking PI3K, mTOR, DNA-PK, and Src kinase signaling to achieve synergistic inhibition. PI3K-IN-16 can be used for research related to PI3K-mediated diseases, such as cancer.
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- CAS No.: 1092788-72-1
- Formule: C17H15N5O2
- Masse moléculaire:321.34
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
mTOR 1.3 μM (IC50) |
In Vitro
Multi-target kinase-IN-15 (PP143) (10 μM ATP) inhibits purified DNA-PK with an IC50 of 0.26 μM, with IC50 values of 1.3-3 μM against PI3-K family members, while showing weaker inhibition against EGFR, EphB4, Src (T/I), and VEGFR[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS No. 1092788-72-1
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Masse moléculaire 321.34
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Formule C17H15N5O2
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SMILES
O=C1C=COC=2C=CC(=CC12)C3=NN(C=4N=CN=C(N)C34)C(C)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Multi-target kinase-IN-15 Related Classifications
HY-134475 Related Classifications
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